Comparison of the organization and fine structure of a chicken and a Xenopus laevis vitellogenin gene.

Détails

ID Serval
serval:BIB_EBD38594A891
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of the organization and fine structure of a chicken and a Xenopus laevis vitellogenin gene.
Périodique
Journal of Biological Chemistry
Auteur(s)
Nardelli D., van het Schip F.D., Gerber-Huber S., Haefliger J.A., Gruber M., Ab G., Wahli W.
ISSN
0021-9258[print], 0021-9258[linking]
Statut éditorial
Publié
Date de publication
1987
Volume
262
Numéro
32
Pages
15377-15385
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The structural organization and the coding nucleotide sequence of the Xenopus laevis A2 and the chicken major vitellogenin genes have been compared. Both genes show the same exon-intron organization. However, the degree of homology between the nucleotide and derived amino acid sequences varies extensively along the genes. Several of the 35 exons are quite similar, and a unique cysteine motif in the lipovitellin II domain is conserved between the two genes. In contrast, one internal region is quite divergent. Part of this region encodes phosvitin, which appears to have evolved rapidly by both point mutations and duplications of serines or short other amino acid stretches. On the basis of these observations, we discuss the possible mechanism of evolution of phosvitin in vertebrates.
Mots-clé
Amino Acid Sequence, Animals, Base Sequence, Chickens, Molecular Sequence Data, Mutation, Phosvitin/genetics, Vitellogenins/genetics, Xenopus laevis
Pubmed
Web of science
Création de la notice
24/01/2008 17:04
Dernière modification de la notice
20/08/2019 17:14
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