Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2.
Details
Serval ID
serval:BIB_EB43D89BAB0D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2.
Journal
Acta ophthalmologica
Working group(s)
MacTel Study Group
Contributor(s)
Bakri S., Bernstein P.S., Blodi B., Brucker A., Bucher F., Chung M., Comer G., Constable I., Cooney M., Do D., Duncan J., Egan C., Elman M.J., Fawzi A., Friedlander M., Gaudric A., Gillies M.C., Goldberg R., Googe J.M., Guymer R., Higgins P., Holz F., Houghton O., Hoyng C.B., Hubschman J.P., Jhaveri C., Khanani A., Lally D., Lee C., Lee M., Miller J.W., Miller D., Moisseiev J., Murphy R., Narayanan R., Randhawa S., Raphaelian P.V., Rich R., Rosen R., Rosenfeld P., Ruys J., Sahel J.A., Schwartz S., Singerman L., Sneed S., Soubrane G., Vingerling J.R., Warrow D., Weinberg D., Wolf S., Wykoff C., Yan J., Yannuzzi L.A., Zhuk S.A.
ISSN
1755-3768 (Electronic)
ISSN-L
1755-375X
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
97
Number
7
Pages
e998-e1005
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
To investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity.
Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral-Domain Optical Coherence Tomograph (SD-OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models.
A total of 134 eyes of 70 patients were included (85 eyes with follow-up, mean 4.7 years, range: 1.4-8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm <sup>2</sup> (p = 0.005). The progression rate was non-linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity.
Ellipsoid zone (EZ) loss in MacTel has a non-linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best-corrected visual acuity by EZ location, which may help routine clinical practice.
Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral-Domain Optical Coherence Tomograph (SD-OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models.
A total of 134 eyes of 70 patients were included (85 eyes with follow-up, mean 4.7 years, range: 1.4-8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm <sup>2</sup> (p = 0.005). The progression rate was non-linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity.
Ellipsoid zone (EZ) loss in MacTel has a non-linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best-corrected visual acuity by EZ location, which may help routine clinical practice.
Keywords
Adult, Aged, Aged, 80 and over, Disease Progression, Female, Fluorescein Angiography/methods, Follow-Up Studies, Fundus Oculi, Humans, Macula Lutea/pathology, Male, Middle Aged, Prognosis, Retinal Pigment Epithelium/pathology, Retinal Telangiectasis/diagnosis, Retinal Vessels/pathology, Time Factors, Tomography, Optical Coherence/methods, Visual Acuity, OCT, MacTel, ellipsoid zone, en face image, macular telangiectasia type 2
Pubmed
Web of science
Create date
15/04/2019 17:38
Last modification date
07/02/2020 7:19
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