The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity.

Details

Serval ID
serval:BIB_EB402400FA5C
Type
Article: article from journal or magazin.
Collection
Publications
Title
The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity.
Journal
Clinical Autonomic Research
Author(s)
Sykiotis G.P., Polyzogopoulou E., Georgopoulos N.A., Trakada G., Spyropoulos K., Kalfarentzos F., Papavassiliou A.G., Vagenakis A.G., Flordellis C.S.
ISSN
0959-9851 (Print)
ISSN-L
0959-9851
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
13
Number
3
Pages
203-207
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
The sympathetic nervous system participates in the regulation of the basal metabolic rate (BMR) and in the manifestation of the obesity-related metabolic syndrome. A deletion/insertion germline polymorphism of the alpha(2B) adrenergic receptor that is associated with reduced agonist-promoted desensitization has been linked to low BMR in obese subjects and to a predisposition to gain weight. This study investigated an association of the alpha(2B) polymorphism with the BMR and metabolic syndrome-related parameters of morbidly obese patients. Genotype frequencies were similar in patients and in a control group. The patients' BMR, adjusted for fat-free mass, fat mass, sex and age, did not differ between alpha(2B) genotypes. The polymorphism was also not associated with the patients' BMI, systolic and diastolic blood pressure, resting heart rate, total and HDL cholesterol, triglycerides, fasting glucose and uric acid levels. These findings do not support a major functional significance of the alpha(2B) adrenergic receptor polymorphism in the present sample of morbidly obese subjects.
Keywords
Adolescent, Adult, Basal Metabolism/genetics, Female, Gene Deletion, Genotype, Humans, Male, Metabolic Syndrome X/genetics, Middle Aged, Obesity, Morbid/genetics, Obesity, Morbid/metabolism, Polymorphism, Genetic, Receptors, Adrenergic, alpha-2/genetics, Rest, Sympathetic Nervous System/physiology
Pubmed
Web of science
Create date
20/01/2015 13:51
Last modification date
20/08/2019 16:13
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