Adults with attention-deficit/hyperactivity disorder - a brain magnetic resonance spectroscopy study.
Details
Serval ID
serval:BIB_EB3C8537A8C2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Adults with attention-deficit/hyperactivity disorder - a brain magnetic resonance spectroscopy study.
Journal
Frontiers in psychiatry
ISSN
1664-0640 (Electronic)
ISSN-L
1664-0640
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
2
Pages
65
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the right midfrontal region including the anterior cingulate cortex in adults with ADHD and healthy controls.
Twenty-nine adults with ADHD and 38 healthy controls were included. We used Proton Magnetic Resonance Imaging with single voxel point-resolved spectroscopy to measure the ratio of glutamate to creatine (Glu/Cre) in the left and the right midfrontal region in the two groups.
The ADHD group showed a significant reduction of Glu/Cre in the left midfrontal region compared to the controls.
The reduction of Glu/Cre in the left midfrontal region in the ADHD group may reflect a glutamatergic deficit in prefrontal neuronal circuitry in adults with ADHD, resulting in problems with cognitive control.
Twenty-nine adults with ADHD and 38 healthy controls were included. We used Proton Magnetic Resonance Imaging with single voxel point-resolved spectroscopy to measure the ratio of glutamate to creatine (Glu/Cre) in the left and the right midfrontal region in the two groups.
The ADHD group showed a significant reduction of Glu/Cre in the left midfrontal region compared to the controls.
The reduction of Glu/Cre in the left midfrontal region in the ADHD group may reflect a glutamatergic deficit in prefrontal neuronal circuitry in adults with ADHD, resulting in problems with cognitive control.
Keywords
ACC, ADHD, Glu/Cre, MR spectroscopy, MRS, cognitive control, cortex cinguli anterior, glutamate
Pubmed
Open Access
Yes
Create date
21/02/2019 10:27
Last modification date
20/08/2019 17:13
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