Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis.

Détails

Ressource 1Télécharger: PMID29503225.pdf (4673.73 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_EB094E4A5E19
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis.
Périodique
EBioMedicine
Auteur(s)
Fregni G., Quinodoz M., Möller E., Vuille J., Galland S., Fusco C., Martin P., Letovanec I., Provero P., Rivolta C., Riggi N., Stamenkovic I.
ISSN
2352-3964 (Electronic)
ISSN-L
2352-3964
Statut éditorial
Publié
Date de publication
03/2018
Peer-reviewed
Oui
Volume
29
Pages
128-145
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Metastasis is a multi-step process in which direct crosstalk between cancer cells and their microenvironment plays a key role. Here, we assessed the effect of paired tumor-associated and normal lung tissue mesenchymal stem cells (MSCs) on the growth and dissemination of primary human lung carcinoma cells isolated from the same patients. We show that the tumor microenvironment modulates MSC gene expression and identify a four-gene MSC signature that is functionally implicated in promoting metastasis. We also demonstrate that tumor-associated MSCs induce the expression of genes associated with an aggressive phenotype in primary lung cancer cells and selectively promote their dissemination rather than local growth. Our observations provide insight into mechanisms by which the stroma promotes lung cancer metastasis.
Mots-clé
Aged, Aged, 80 and over, Animals, Biomarkers, Cell Communication, Disease Models, Animal, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms/genetics, Lung Neoplasms/metabolism, Lung Neoplasms/pathology, Male, Mesenchymal Stromal Cells/metabolism, Mice, Middle Aged, Neoplasm Grading, Neoplasm Metastasis, Neoplasm Staging, Transcriptome, Tumor Microenvironment/genetics, Xenograft Model Antitumor Assays, ADAMTS12, GREM1, ITGA11, LOXL2, Tumor-associated MSCs, lung cancer, metastasis
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/03/2018 15:44
Dernière modification de la notice
20/08/2019 17:13
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