Case report: Rectal adminstration of ivermectin to a patient with Strongyloides hyperinfection syndrome

Details

Serval ID
serval:BIB_EAB4E07CD6A6
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Case report: Rectal adminstration of ivermectin to a patient with Strongyloides hyperinfection syndrome
Journal
American Journal of Tropical Medicine and Hygiène
Author(s)
Tarr  P. E., Miele  P. S., Peregoy  K. S., Smith  M. A., Neva  F. A., Lucey  D. R.
ISSN
0002-9637
Publication state
Published
Issued date
04/2003
Peer-reviewed
Oui
Volume
68
Number
4
Pages
453-5
Notes
Case Reports
Journal Article --- Old month value: Apr
Abstract
Strongyloides hyperinfection syndrome may be complicated by paralytic ileus that interferes with the absorption of oral anti-helminthics. We report on the administration of ivermectin as a rectal enema preparation to a renal transplant recipient with Strongyloides hyperinfection syndrome and progressive ileus. Attempts at treatment using nasogastric albendazole and ivermectin were unsuccessful despite clamping the nasogastric tube after drug administration. Ivermectin tablets were ground to a powder, resuspended in a commercially available suspending agent, and administered per rectum. The suspending agent was chosen for its near-physiologic osmolality to allow longer retention, in contrast to many enema preparations that have a laxative effect. The patient improved markedly within 72 hours of initiation of the therapy per rectum and recovered fully. Ivermectin administered as an enema may be beneficial in patients with severe strongyloidiasis who are unable to absorb or tolerate oral therapy.
Keywords
Administration, Rectal Antinematodal Agents/*administration & dosage Enema Female Humans Immunocompromised Host Intestinal Pseudo-Obstruction/*etiology/physiopathology Ivermectin/*administration & dosage Middle Aged Strongyloidiasis/complications/*drug therapy Treatment Outcome
Pubmed
Web of science
Create date
20/01/2008 17:55
Last modification date
20/08/2019 17:13
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