Molecular determinants of human adipose tissue: differences between visceral and subcutaneous compartments in obese women
Details
Serval ID
serval:BIB_EA07541463AD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Molecular determinants of human adipose tissue: differences between visceral and subcutaneous compartments in obese women
Journal
Journal of Clinical Endocrinology and Metabolism
ISSN
0021-972X (Print)
Publication state
Published
Issued date
03/2004
Volume
89
Number
3
Pages
1379-84
Notes
Journal Article --- Old month value: Mar
Abstract
The adipose tissue is playing an important role in the development of human obesity and its related comorbidities, but little is known about the mechanisms governing its differentiation and proliferation. In this work, we studied the expression of transcription factors involved in fat storage and metabolic regulations in adipose tissue of 50 well-characterized obese women. In multivariate analyses, 80% of c enhancer binding protein alpha (cEBP alpha), c and a sterol regulatory element binding protein 1 (c and a SREBP1), and retinoid X receptor (RXR alpha) levels in sc adipose tissue (SAT) could be explained by other transcription factors. In addition, RXR alpha was the major determinant of peroxisome proliferator and activated receptor-gamma 1 variability in SAT, with the two factors being involved in the determination of the variability of insulin resistance. In contrast, the levels of all these transcription factors, together with various phenotypic and biological characteristics of the patients, seemed to participate only marginally in the regulation of visceral adipose tissue activity. In similar multivariate analyses, they could explain only a minor part of the variability of cEBP alpha, c and a SREBP1, or RXR alpha, suggesting the involvement of other regulators. Overall, our results demonstrate a different regulation of visceral adipose tissue and SAT and a different role of both tissues in insulin resistance and lipid storage.
Keywords
Adipose Tissue/*cytology/*physiology
Adult
CCAAT-Enhancer-Binding Proteins/genetics
Cell Differentiation/physiology
Cell Division/physiology
DNA-Binding Proteins/genetics
Female
Gene Expression
Humans
Middle Aged
Obesity/*pathology/*physiopathology
Phenotype
Receptors, Cytoplasmic and Nuclear/genetics
Receptors, Retinoic Acid/genetics
Regression Analysis
Retinoid X Receptors
Sterol Regulatory Element Binding Protein 1
Subcutaneous Tissue/physiology
Transcription Factors/genetics
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 17:26
Last modification date
20/08/2019 17:12