A phantom study to determine the theoretical accuracy and precision of radial MRI to measure cross-sectional area differences for the application of coronary endothelial function assessment.

Details

Serval ID
serval:BIB_E9D3315FE1C7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A phantom study to determine the theoretical accuracy and precision of radial MRI to measure cross-sectional area differences for the application of coronary endothelial function assessment.
Journal
Magnetic resonance in medicine
Author(s)
Yerly J., Gubian D., Knebel J.F., Schenk A., Chaptinel J., Ginami G., Stuber M.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Publication state
Published
Issued date
01/2018
Peer-reviewed
Oui
Volume
79
Number
1
Pages
108-120
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
MRI has been used to noninvasively assess coronary endothelial function by measuring the vasoreactivity in response to handgrip exercise. However, the spatial resolution of MRI is limited relative to the expected vasodilation response of healthy coronary arteries (10%-20%), and the sensitivity of MRI to detect such small cross-sectional area differences has yet to be quantitatively examined.
Holes of different diameters were drilled in a phantom to simulate a range of physiological responses of coronary arteries to stress. Radial cine MR images with different spatial resolutions were acquired under moving conditions, and different noise levels were simulated. Cross-sectional areas were automatically measured and statistically analyzed to quantify the smallest detectable area difference.
Statistical analyses suggest that radial MRI is capable of distinguishing area differences of 0.2 to 0.3 mm2 for high signal-to-noise ratio images, which correspond to a percentage coronary area difference of 3% to 4% for a 3-mm baseline diameter. Furthermore, the smallest detectable area difference was largely independent of the pixel size for the sequence and range of diameters investigated in this study.
Radial MRI is capable of reliably detecting small differences in cross-sectional areas that are well within the expected physiological range of stress-induced area changes in of healthy coronary arteries. Magn Reson Med 79:108-120, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Keywords
Coronary, accuracy, endothelial function, limit of detection, precision, radial MRI, vasodilation, vasoreactivity
Pubmed
Web of science
Create date
14/03/2017 11:16
Last modification date
22/08/2019 8:27
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