Metabolic and physiologic effects of an endotoxin challenge in healthy obese subjects.

Details

Serval ID
serval:BIB_E9BEF4648ED3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metabolic and physiologic effects of an endotoxin challenge in healthy obese subjects.
Journal
Clinical Physiology and Functional Imaging
Author(s)
Rohrer M., Berger M.M., Pittet Y.K., Delodder F., Tappy L., Feihl F., Chioléro R.L.
ISSN
1475-097X (Electronic)
ISSN-L
1475-0961
Publication state
Published
Issued date
2011
Volume
31
Number
5
Pages
371-375
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Aim: The obesity epidemic has increased the number of obese patients admitted to the ICU. In vitro studies suggest that adipose tissue response to inflammation is enhanced: in vivo data are not conclusive yet. The aim of this study was to test the physiologic response of healthy obese subjects to a standardized intravenous LPS challenge.Methods: Prospective single-blind, randomized, cross-over study in eight subjects (four men, four women), aged 34 +/- 7 years, BMI 34.7 +/- 4.2, without glucose intolerance and lipid abnormalities, testing the impact of intravenous LPS (2 ng kg(-1) of actual body weight) versus placebo.Results: Temperature, hemodynamic variables, indirect calorimetry and blood samples (TNF-alpha, IL-6, stress hormones, hs-CRP) were collected. After LPS temperature, heart rate. TNF-alpha and IL-6 concentrations and stress hormones (cortisol and glucagon) increased significantly, with maximal responses between 120 and 240 min after the injection. The pattern, the timing and the magnitude of change were similar to those observed in lean subjects.Conclusion: This study shows that healthy obese subjects have a similar response pattern to intravenous LPS as described in lean subjects.
Pubmed
Web of science
Create date
09/09/2011 9:56
Last modification date
20/08/2019 16:12
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