Comparison of integrin αvβ3 expression with 68Ga-NODAGA-RGD PET/CT and glucose metabolism with 18F-FDG PET/CT in esophageal or gastroesophageal junction cancers.

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License: CC BY 4.0
Serval ID
serval:BIB_E9AFEE73E354
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of integrin αvβ3 expression with 68Ga-NODAGA-RGD PET/CT and glucose metabolism with 18F-FDG PET/CT in esophageal or gastroesophageal junction cancers.
Journal
European journal of hybrid imaging
Author(s)
Dietz M., Dunet V., Mantziari S., Pomoni A., Dias Correia R., Testart Dardel N., Boughdad S., Nicod Lalonde M., Treglia G., Schafer M., Schaefer N., Prior J.O.
ISSN
2510-3636 (Electronic)
ISSN-L
2510-3636
Publication state
Published
Issued date
01/02/2023
Peer-reviewed
Oui
Volume
7
Number
1
Pages
3
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of <sup>68</sup> Ga-NODAGA-RGD PET/CT with that of <sup>18</sup> F-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination.
Ten <sup>68</sup> Ga-NODAGA-RGD and ten <sup>18</sup> F-FDG PET/CT were performed in nine prospectively included participants (1 woman; aged 58 ± 8.4 y, range 40-69 y). Maximum SUV (SUV <sub>max</sub> ) and metabolic tumor volumes (MTV) were calculated. The Mann-Whitney U test and Spearman correlation analysis (ρ) were used.
<sup>68</sup> Ga-NODAGA-RGD PET/CT detected positive uptake in 10 primary sites (8 for primary tumors and 2 for local relapse suspicion), 6 lymph nodes and 3 skeletal sites. <sup>18</sup> F-FDG PET/CT detected positive uptake in the same sites but also in 16 additional lymph nodes and 1 adrenal gland. On a lesion-based analysis, SUV <sub>max</sub> of <sup>18</sup> F-FDG was significantly higher than those of <sup>68</sup> Ga-NODAGA-RGD (4.9 [3.7-11.3] vs. 3.2 [2.6-4.2] g/mL, p = 0.014). Only one participant showed a higher SUV <sub>max</sub> in an osseous metastasis with <sup>68</sup> Ga-NODAGA-RGD as compared to <sup>18</sup> F-FDG (6.6 vs. 3.9 g/mL). Correlation analysis showed positive correlation between <sup>18</sup> F-FDG and <sup>68</sup> Ga-NODAGA-RGD PET parameters (ρ = 0.56, p = 0.012 for SUV <sub>max</sub> , ρ = 0.78, p < 0.001 for lesion-to-background ratios and ρ = 0.58, p = 0.024 for MTV). We observed that <sup>18</sup> F-FDG uptake was homogenous inside all the confirmed primary sites (n = 9). In contrast, <sup>68</sup> Ga-NODAGA-RGD PET showed more heterogenous uptake in 6 out of the 9 confirmed primary sites (67%), seen mostly in the periphery of the tumor in 5 out of the 9 confirmed primary sites (56%), and showed slight extensions into perilesional structures in 5 out of the 9 confirmed primary sites (56%).
In conclusion, <sup>68</sup> Ga-NODAGA-RGD has lower potential in the detection of esophageal or esophagogastric junction malignancies compared to <sup>18</sup> F-FDG. However, the results suggest that PET imaging of integrin α <sub>v</sub> β <sub>3</sub> expression may provide complementary information and could aid in tumor diversity and delineation.
Trial registration: NCT02666547. Registered January 28, 2016-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02666547 .
Keywords
18F-FDG, 68Ga-NODAGA-RGD, Angiogenesis, Esophageal cancer, Integrin α v β 3, PET
Pubmed
Web of science
Open Access
Yes
Create date
27/02/2023 9:16
Last modification date
08/03/2023 7:14
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