Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Usefulness of helium-oxygen mixtures in the treatment of mechanically ventilated patients.
Current Opinion in Critical Care
Publication types: Journal Article ; ReviewPublication Status: ppublish
The density of helium is markedly lower than that of air or any of its components, leading to a substantial decrease in airway resistance to flow when it is inhaled. In mechanically ventilated patients with obstructive airway disease, replacing the usual air-oxygen mixture with helium-oxygen has been shown to reduce dynamic hyperinflation and intrinsic positive end-expiratory pressure; to decrease lung inflation pressures, respiratory acidosis, and work of breathing; and to improve arterial blood gases. Aerosol delivery to distal airways is enhanced with helium-oxygen. Preliminary data also suggest that the use of helium-oxygen could be a valuable approach to decrease postextubation respiratory distress. However, interference with ventilator function and added costs are two major disadvantages of helium-oxygen. Hence, before its widespread use in mechanically ventilated patients can be recommended, studies are needed to determine whether these favorable short-term effects can influence patient outcome.
Anoxia/physiopathology, Helium/therapeutic use, Humans, Oxygen/therapeutic use, Pulmonary Disease, Chronic Obstructive/physiopathology, Pulmonary Disease, Chronic Obstructive/therapy, Respiration, Artificial, Respiratory Mechanics, Respiratory Tract Diseases/physiopathology, Respiratory Tract Diseases/therapy, Tidal Volume
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