Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies.

Details

Ressource 1Download: 27784531_BIB_E96F54C078BB.pdf (677.00 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_E96F54C078BB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies.
Journal
Euro surveillance
Author(s)
Mertz D., Fadel S.A., Srigley J.A., Asner S.A., Loeb M.
ISSN
1560-7917 (Electronic)
ISSN-L
1025-496X
Publication state
Published
Issued date
20/10/2016
Peer-reviewed
Oui
Volume
21
Number
42
Pages
42-44
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
Publication Status: ppublish
Abstract
Influenza vaccination programmes are assumed to have a herd effect and protect contacts of vaccinated persons from influenza virus infection. We searched MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Global Health and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to March 2014 for studies assessing the protective effect of influenza vaccination vs no vaccination on influenza virus infections in contacts. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using a random-effects model. Of 43,082 screened articles, nine randomised controlled trials (RCTs) and four observational studies were eligible. Among the RCTs, no statistically significant herd effect on the occurrence of influenza in contacts could be found (OR: 0.62; 95% CI: 0.34-1.12). The one RCT conducted in a community setting, however, showed a significant effect (OR: 0.39; 95% CI: 0.26-0.57), as did the observational studies (OR: 0.57; 95% CI: 0.43-0.77). We found only a few studies that quantified the herd effect of vaccination, all studies except one were conducted in children, and the overall evidence was graded as low. The evidence is too limited to conclude in what setting(s) a herd effect may or may not be achieved.

Keywords
Humans, Influenza Vaccines/administration & dosage, Influenza, Human/prevention & control, Observational Studies as Topic, Randomized Controlled Trials as Topic, Vaccination, herd effect, indirect effect, influenza, systematic review, vaccine-preventable diseases, vaccines and immunisation
Pubmed
Web of science
Open Access
Yes
Create date
25/09/2017 14:16
Last modification date
20/08/2019 16:12
Usage data