Article: article from journal or magazin.
Biochemical and behavioral changes in rats after prolonged treatment with desipramine: interaction with p-chlorophenylalanine
Naunyn-Schmiedeberg's Archives of Pharmacology
Journal Article --- Old month value: Oct
The decrease in the Bmax value of 3H-dihydroalprenolol (3H-DHA) binding to cortical membranes of rat brain induced by long-term administration of desipramine (DMI) was prevented by concomitant treatment with parachlorophenylalanine (pCPA). Acute administration of DMI significantly decreased locomotor activity in saline- and (pCPA)-pretreated rats. DMI-induced inhibition of locomotor activity was abolished in (pCPA)-pretreated rats chronically treated with DMI. Conversely, in pCPA-pretreated animals, acute DMI could still significantly decrease the locomotion of chronically DMI-treated rats. The data presented indicate that an intact serotoninergic system is required to enable antidepressant drugs to induce biochemical and behavioral changes following their chronic administration.
Animals Brain Chemistry/*drug effects Desipramine/*pharmacology Drug Interactions Fenclonine/*pharmacology Kinetics Male Motor Activity/*drug effects Rats Rats, Inbred Strains Serotonin/biosynthesis
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