Cognition-enhancing effects of donepezil in traumatic brain injury.

Détails

ID Serval
serval:BIB_E94A5C172744
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cognition-enhancing effects of donepezil in traumatic brain injury.
Périodique
European Neurology
Auteur(s)
Khateb A., Ammann J., Annoni J.M., Diserens K.
ISSN
0014-3022
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
54
Numéro
1
Pages
39-45
Langue
anglais
Résumé
The purpose of this study was to investigate the effects of donepezil, a cholinergic agent, on chronic cognitive impairment due to traumatic brain injury (TBI). Chronic patients underwent two standardized neuropsychological evaluations--one before and the other 3 months following treatment with donepezil. Together with global inventories that appraised behaviour, fatigue, anxiety and depression, these evaluations also assessed executive functioning, memory and attention. Of the 10 patients who followed the therapy, 8 reported subjective improvement in at least one cognitive domain following therapy and most of them reported better functioning in everyday activities. This effect was supported by a slight global improvement when considering the global score of the different affectivo-behavioural scales. At the neuropsychological level, although we could observe a slight improvement in the majority of the considered tests, significant positive changes were mainly found in tests assessing speed of processing, learning and divided attention. These findings suggest that donepezil may lead to better general functioning and improve attentional skills in patients with chronic TBI.
Mots-clé
Adult, Brain Injuries, Cholinesterase Inhibitors, Cognition, Cognition Disorders, Female, Humans, Indans, Male, Middle Aged, Neuropsychological Tests, Piperidines, Treatment Outcome
Pubmed
Web of science
Création de la notice
25/01/2008 12:37
Dernière modification de la notice
20/08/2019 17:11
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