Estimated daily intake of phthalates in occupationally exposed groups

Details

Serval ID
serval:BIB_E917D37864D5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Estimated daily intake of phthalates in occupationally exposed groups
Journal
Journal of Exposure Science & Environmental Epidemiology
Author(s)
Hines Cynthia J., Hopf Nancy B., Deddens James A., Silva Manori J., Calafat Antonia M.
ISSN
1559-064X (Electronic)
ISSN-L
1559-0631
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
21
Number
2
Pages
133-141
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Improved analytical methods for measuring urinary phthalate metabolites have resulted in biomarker-based estimates of phthalate daily intake for the general population, but not for occupationally exposed groups. In 2003-2005, we recruited 156 workers from eight industries where materials containing diethyl phthalate (DEP), dibutyl phthalate (DBP), and/or di(2-ethylhexyl) phthalate (DEHP) were used as part of the worker's regular job duties. Phthalate metabolite concentrations measured in the workers' end-shift urine samples were used in a simple pharmacokinetic model to estimate phthalate daily intake. DEHP intake estimates based on three DEHP metabolites combined were 0.6-850 μg/kg/day, with the two highest geometric mean (GM) intakes in polyvinyl chloride (PVC) film manufacturing (17 μg/kg/day) and PVC compounding (12 μg/kg/day). All industries, except phthalate manufacturing, had some workers whose DEHP exposure exceeded the U.S. reference dose (RfD) of 20 μg/kg/day. A few workers also exceeded the DEHP European tolerable daily intake (TDI) of 50 μg/kg/day. DEP intake estimates were 0.5-170 μg/kg/day, with the highest GM in phthalate manufacturing (27 μg/kg/day). DBP intake estimates were 0.1-76 μg/kg/day, with the highest GMs in rubber gasket and in phthalate manufacturing (17 μg/kg/day, each). No DEP or DBP intake estimates exceeded their respective RfDs. The DBP TDI (10 μg/kg/day) was exceeded in three rubber industries and in phthalate manufacturing. These intake estimates are subject to several uncertainties; however, an occupational contribution to phthalate daily intake is clearly indicated in some industries.

Keywords
Biomarkers/urine, Chemical Industry, Dibutyl Phthalate/pharmacokinetics, Dibutyl Phthalate/urine, Diethylhexyl Phthalate/pharmacokinetics, Diethylhexyl Phthalate/urine, Environmental Monitoring/methods, Female, Humans, Male, Occupational Exposure/analysis, Phthalic Acids/pharmacokinetics, Phthalic Acids/urine, Polyvinyl Chloride/metabolism, Polyvinyl Chloride/pharmacokinetics, Risk Assessment, Uncertainty
Pubmed
Web of science
Open Access
Yes
Create date
06/10/2011 16:45
Last modification date
20/08/2019 17:11
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