Standardized benchmarking in the quest for orthologs.

Détails

ID Serval
serval:BIB_E8F5620D5F4F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Standardized benchmarking in the quest for orthologs.
Périodique
Nature Methods
Auteur(s)
Altenhoff A.M., Boeckmann B., Capella-Gutierrez S., Dalquen D.A., DeLuca T., Forslund K., Huerta-Cepas J., Linard B., Pereira C., Pryszcz L.P., Schreiber F., da Silva A.S., Szklarczyk D., Train C.M., Bork P., Lecompte O., von Mering C., Xenarios I., Sjölander K., Jensen L.J., Martin M.J., Muffato M., Gabaldón T., Gabaldón T., Lewis S.E., Thomas P.D., Sonnhammer E., Dessimoz C.
Collaborateur(s)
Quest for Orthologs consortium
Contributeur(s)
Altenhoff AM., Boeckmann B., Capella-Gutierrez S., DeLuca T., Forslund K., Huerta-Cepas J., Linard B., Pereira C., Pryszcz LP., Schreiber F., da Silva AS. , Szklarczyk D., Train CM., Lecompte O., Xenarios I., Sjölander K., Martin MJ., Muffato M., Gabaldón T., Lewis SE., Thomas PD., Sonnhammer E., Dessimoz C.
ISSN
1548-7105 (Electronic)
ISSN-L
1548-7091
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
13
Numéro
5
Pages
425-430
Langue
anglais
Résumé
Achieving high accuracy in orthology inference is essential for many comparative, evolutionary and functional genomic analyses, yet the true evolutionary history of genes is generally unknown and orthologs are used for very different applications across phyla, requiring different precision-recall trade-offs. As a result, it is difficult to assess the performance of orthology inference methods. Here, we present a community effort to establish standards and an automated web-based service to facilitate orthology benchmarking. Using this service, we characterize 15 well-established inference methods and resources on a battery of 20 different benchmarks. Standardized benchmarking provides a way for users to identify the most effective methods for the problem at hand, sets a minimum requirement for new tools and resources, and guides the development of more accurate orthology inference methods.
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/04/2016 16:31
Dernière modification de la notice
20/08/2019 16:11
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