Article: article from journal or magazin.
Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells.
Publication types: Journal Article ; ReviewPublication Status: ppublish
Suppression by T-regulatory (Tr) cells is essential for the induction of T-cell tolerance and the prevention of autoimmune diseases, organ rejection, and graft-versus-host disease. Increasing attention has been devoted to understand the role of dendritic cells (DC) in the control of Tr-cell differentiation. Here we review the recent evidence that cluster designation (CD)40-ligand activated plasmacytoid-derived DCs (DC2) have the ability to induce primary Tr-cell differentiation. We propose that in addition to the regulatory functions of immature myeloid DC, Tr-cell induction by DC2 represents a nonredundant mechanism for the safeguard of peripheral T-cell tolerance. DC2 can be used as tool to drive potent antigen specific Tr-cell differentiation and expansion in vitro and in vivo.
CD4-Positive T-Lymphocytes/immunology, Cell Differentiation/immunology, Dendritic Cells/immunology, Dendritic Cells/physiology, Humans, Immune Tolerance/immunology, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/immunology, T-Lymphocytes/immunology
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