Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells.

Details

Serval ID
serval:BIB_E8EF589A0BCF
Type
Article: article from journal or magazin.
Collection
Publications
Title
Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells.
Journal
Human Immunology
Author(s)
Gilliet M., Liu Y.J.
ISSN
0198-8859 (Print)
ISSN-L
0198-8859
Publication state
Published
Issued date
2002
Volume
63
Number
12
Pages
1149-1155
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
Suppression by T-regulatory (Tr) cells is essential for the induction of T-cell tolerance and the prevention of autoimmune diseases, organ rejection, and graft-versus-host disease. Increasing attention has been devoted to understand the role of dendritic cells (DC) in the control of Tr-cell differentiation. Here we review the recent evidence that cluster designation (CD)40-ligand activated plasmacytoid-derived DCs (DC2) have the ability to induce primary Tr-cell differentiation. We propose that in addition to the regulatory functions of immature myeloid DC, Tr-cell induction by DC2 represents a nonredundant mechanism for the safeguard of peripheral T-cell tolerance. DC2 can be used as tool to drive potent antigen specific Tr-cell differentiation and expansion in vitro and in vivo.
Keywords
CD4-Positive T-Lymphocytes/immunology, Cell Differentiation/immunology, Dendritic Cells/immunology, Dendritic Cells/physiology, Humans, Immune Tolerance/immunology, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Create date
19/11/2012 18:33
Last modification date
20/08/2019 16:11
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