Diagnostic Approach to Neuroendocrine Neoplasms of the Gastrointestinal Tract and Pancreas.

Détails

ID Serval
serval:BIB_E8B86E8B7FCD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Diagnostic Approach to Neuroendocrine Neoplasms of the Gastrointestinal Tract and Pancreas.
Périodique
Türk Patoloji Dergisi
Auteur(s)
Uccella S., Sessa F., La Rosa S.
ISSN
1018-5615 (Print)
ISSN-L
1018-5615
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
31
Numéro
Suppl 1
Pages
113-127
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
The gastroenteropancreatic (GEP) system is the site of origin of about two thirds of all neuroendocrine neoplasms (NENs) of the human body. GEP-NENs encompass a wide spectrum of entities, from very indolent tumors to highly aggressive carcinomas. They represent a challenge for the oncologist and a correct diagnostic approach is crucial for the management of patients. The nomenclature and classification of these tumors have been a matter of debate for more than a century, since their first description by Siegfried Oberdorfer. The last WHO classification provided a robust and easy-to-use tool to prognostically stratify GEP-NENs, based on morphological aspects and on proliferation rate. This review examines current approaches to the diagnosis and prognostic classification of GEP-NENs, focusing on the critical use of morphological parameters and immunohistochemical stainings, including diagnostic, site-specific and prognostic markers. The key issues of the current classification are addressed, including the emerging topics about cases with discordant morphology and proliferative index. Finally, we attempted to highlight the diagnostic pitfalls and the caveats in the use of immunohistochemical stains.
Mots-clé
Biomarkers, Tumor/analysis, Biopsy, Carcinoma, Neuroendocrine/chemistry, Carcinoma, Neuroendocrine/classification, Diagnostic Errors/prevention & control, Gastrointestinal Neoplasms/chemistry, Gastrointestinal Neoplasms/classification, Humans, Immunohistochemistry, Multimodal Imaging/methods, Pancreatic Neoplasms/chemistry, Pancreatic Neoplasms/classification, Positron-Emission Tomography, Predictive Value of Tests, Prognosis, Tomography, X-Ray Computed
Pubmed
Open Access
Oui
Création de la notice
06/09/2016 11:48
Dernière modification de la notice
20/08/2019 16:11
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