Number of Edb motor units estimated using an adapted multiple point stimulation method: normal values and longitudinal studies in ALS and peripheral neuropathies.

Détails

ID Serval
serval:BIB_E7E2F2EABCE8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Number of Edb motor units estimated using an adapted multiple point stimulation method: normal values and longitudinal studies in ALS and peripheral neuropathies.
Périodique
Clinical Neurophysiology
Auteur(s)
Albrecht E., Kuntzer T.
ISSN
1388-2457 (Print)
ISSN-L
1388-2457
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
115
Numéro
3
Pages
557-563
Langue
anglais
Notes
Publication types: Journal Article ; Validation Studies Publication Status: ppublish
Résumé
OBJECTIVE: To validate the adapted multiple point stimulation (AMPS) method to estimate the number of motor units (MUNE) from the extensor digitorum brevis (Edb) muscle.
METHODS: Twenty controls (10 young and 10 old) were examined on both sides and 10 patients with amyotrophic lateral sclerosis (ALS) and 5 with acute peripheral neuropathy (PN) were examined longitudinally on one side during a series of repeated electrophysiological sessions.
RESULTS: In the controls, the median MUNE and size of the motor unit action potentials (S-MUAPs) were found to be age-related (411 and 70 microVms in the young group; 164 and 142 microVms in the old group; P < 0.01), with a coefficient of variation of MUNE values of 27% and 20%, respectively. In the ALS group, the median MUNE value at diagnosis was 31 (P < 0.05 vs. controls), and during a mean follow-up period of 11.5 months a continuous decrease in the MUNE value was seen, together with an initial increase, followed by a later decrease in 4 cases, in S-MUAP size. In the PN group, the MUNE value was initially similar to that in controls, but then decreased, accompanied by an increase in S-MUAP size, and then showed a progressive increase, together with a decrease in S-MUAP size.
CONCLUSIONS: AMPS, a MUNE method developed in the upper extremity, also appears to be a useful procedure for quantifying changes in the MUNE value in the Edb muscle without specific software in order to study age-related changes or changes in patients with ALS or PN.
Mots-clé
Acute Disease, Adult, Aged, Amyotrophic Lateral Sclerosis/physiopathology, Case-Control Studies, Cell Count, Electric Stimulation/methods, Electromyography/methods, Female, Humans, Longitudinal Studies, Male, Middle Aged, Motor Neurons, Muscle, Skeletal/innervation, Muscle, Skeletal/physiopathology, Neuromuscular Junction/physiopathology, Peripheral Nervous System Diseases/physiopathology, Toes
Pubmed
Web of science
Création de la notice
25/01/2008 13:43
Dernière modification de la notice
20/08/2019 17:10
Données d'usage