Polyunsaturated fatty acid deficiency reverses effects of alcohol on mitochondrial energy metabolism

Details

Serval ID
serval:BIB_E78A923A562C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Polyunsaturated fatty acid deficiency reverses effects of alcohol on mitochondrial energy metabolism
Journal
Journal of Hepatology
Author(s)
Piquet  M. A., Roulet  M., Nogueira  V., Filippi  C., Sibille  B., Hourmand-Ollivier  I., Pilet  M., Rouleau  V., Leverve  X. M.
ISSN
0168-8278 (Print)
Publication state
Published
Issued date
11/2004
Volume
41
Number
5
Pages
721-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
BACKGROUND/AIMS: Polyunsaturated fatty acids (PUFA) deficiency is common in patients with alcoholic liver disease. The suitability of reversing such deficiency remains controversial. The aim was to investigate the role played by PUFA deficiency in the occurrence of alcohol-related mitochondrial dysfunction. METHODS: Wistar rats were fed either a control diet with or without alcohol (control and ethanol groups) or a PUFA deficient diet with or without alcohol (PUFA deficient and PUFA deficient+ethanol groups). After 6 weeks, liver mitochondria were isolated for energetic studies and fatty acid analysis. RESULTS: Mitochondria from ethanol fed rats showed a dramatic decrease in oxygen consumption rates and in cytochrome oxidase activity. PUFA deficiency showed an opposite picture. PUFA deficient+ethanol group roughly reach control values, regarding cytochrome oxidase activity and respiratory rates. The relationship between ATP synthesis and respiratory rate was shifted to the left in ethanol group and to the right in PUFA-deficient group. The plots of control and PUFA deficient+ethanol groups were overlapping. Phospholipid arachidonic over linoleic ratio closely correlated to cytochrome oxidase and oxygen uptake. CONCLUSIONS: PUFA deficiency reverses alcohol-related mitochondrial dysfunction via an increase in phospholipid arachidonic over linoleic ratio, which raises cytochrome oxidase activity. Such deficiency may be an adaptive mechanism.
Keywords
Animal Feed Animals Dietary Fats/pharmacology Energy Metabolism/drug effects/*physiology Fatty Acids, Unsaturated/*deficiency/pharmacology Liver Diseases, Alcoholic/diet therapy/*metabolism Male Mitochondria, Liver/*metabolism Oxygen Consumption/drug effects/physiology Rats Rats, Wistar
Pubmed
Web of science
Create date
24/01/2008 20:33
Last modification date
20/08/2019 16:10
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