Can the Lateral Habenula Crack the Serotonin Code?

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_E77F1ECD6974
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Can the Lateral Habenula Crack the Serotonin Code?
Journal
Frontiers in Synaptic Neuroscience
Author(s)
Tchenio A., Valentinova K., Mameli M.
ISSN-L
1663-3563
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
8
Pages
34
Language
english
Abstract
The lateral habenula (LHb) and the serotonergic system both contribute to motivational states by encoding rewarding and aversive signals. Converging evidence suggests that perturbation of these systems is critical for the pathophysiology of mood disorders. Anatomical and functional studies indicate that the serotonergic system and the LHb are interconnected in a forward-feedback loop. However, how serotonin release modifies the synaptic and cellular properties of LHb neurons and whether this has any behavioral repercussions remain poorly investigated. In this review article, we discuss insights gained from rodents and humans regarding the implications of the serotonin system and the LHb in aversion encoding and related disorders. We then describe the type, properties and pharmacology of serotonergic receptors expressed throughout the LHb. Finally, we discuss physiological data reporting how serotonergic signaling modifies synaptic transmission and neuronal activity within the LHb. Altogether, we combine a mechanistic- and circuit-level knowledge to provide an overview on how the LHb integrates serotonergic signals, a process potentially contributing to LHb-dependent encoding of valenced external stimuli.

Pubmed
Open Access
Yes
Create date
31/01/2017 11:08
Last modification date
20/08/2019 16:10
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