Congenital hydronephrosis: prenatal diagnosis and epidemiology in Europe.
Details
Serval ID
serval:BIB_E76CC8E4831D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Congenital hydronephrosis: prenatal diagnosis and epidemiology in Europe.
Journal
Journal of Pediatric Urology
Working group(s)
Eurocat Working Group
Contributor(s)
Salvador£££Joaquín£££ J. , Latos-Bielenska A., Portillo I., Haeusler M., Addor MC., Bakker MK., Scarano G., Wiesel A., Costigan J., O'Mahony MT., Tucker D., de Vigan C., Calzolari E., Doray B., Gatt M., Ariceta G., Gillerot Y.
ISSN
1873-4898 (Electronic)
ISSN-L
1477-5131
Publication state
Published
Issued date
2009
Volume
5
Number
1
Pages
47-52
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Abstract
OBJECTIVE: To describe prevalence, prenatal diagnosis and epidemiology of congenital hydronephrosis (CH) in Europe.
MATERIAL AND METHOD: Data from a large European database for surveillance of congenital malformations (EUROCAT). The 20 participating registries are all based on multiple sources of information and include information about livebirths, fetal deaths with gestational age >or=20 weeks and terminations of pregnancy after prenatal diagnosis of malformations. Included were all cases with CH and born 1995-2004.
RESULTS: There were 3648 cases with CH giving an overall prevalence of 11.5 cases per 10,000 births. The large majority of cases were livebirths (3506, 96% of total) and only 17 cases were fetal deaths and 120 were terminations of pregnancy. Almost all livebirths were alive 1 week after birth. Boys accounted for 72% of all cases. A high proportion of the cases (86%) had an isolated renal malformation. There were large regional differences in prevalence of CH ranging from 2 to 29 per 10,000 births. There was little regional variation in the prevalence of postnatally diagnosed cases while there were large regional differences in prevalence of prenatally diagnosed cases.
CONCLUSION: Cases with CH are mainly livebirths, boys and survive the first week after birth. The large difference in prevalence seems to be related to the availability of prenatal screening in the region. The impact of over-diagnosis and potential over-treatment in regions with high prevalence or under-diagnosis with implications for renal function later in life in regions with low prevalence needs further investigation.
MATERIAL AND METHOD: Data from a large European database for surveillance of congenital malformations (EUROCAT). The 20 participating registries are all based on multiple sources of information and include information about livebirths, fetal deaths with gestational age >or=20 weeks and terminations of pregnancy after prenatal diagnosis of malformations. Included were all cases with CH and born 1995-2004.
RESULTS: There were 3648 cases with CH giving an overall prevalence of 11.5 cases per 10,000 births. The large majority of cases were livebirths (3506, 96% of total) and only 17 cases were fetal deaths and 120 were terminations of pregnancy. Almost all livebirths were alive 1 week after birth. Boys accounted for 72% of all cases. A high proportion of the cases (86%) had an isolated renal malformation. There were large regional differences in prevalence of CH ranging from 2 to 29 per 10,000 births. There was little regional variation in the prevalence of postnatally diagnosed cases while there were large regional differences in prevalence of prenatally diagnosed cases.
CONCLUSION: Cases with CH are mainly livebirths, boys and survive the first week after birth. The large difference in prevalence seems to be related to the availability of prenatal screening in the region. The impact of over-diagnosis and potential over-treatment in regions with high prevalence or under-diagnosis with implications for renal function later in life in regions with low prevalence needs further investigation.
Keywords
Diagnosis, Differential, Europe/epidemiology, Female, Humans, Hydronephrosis/congenital, Hydronephrosis/diagnosis, Incidence, Infant, Newborn, Male, Pregnancy, Prenatal Diagnosis/methods, Prevalence, Retrospective Studies
Pubmed
Web of science
Create date
31/03/2009 11:53
Last modification date
20/08/2019 17:10
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