Smoking cessation and the incidence of pre-diabetes and type 2 diabetes: a cohort study.

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Ressource 1Télécharger: BIB_E73E43DF5A63.P001.pdf (739.47 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_E73E43DF5A63
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Smoking cessation and the incidence of pre-diabetes and type 2 diabetes: a cohort study.
Périodique
Journal of Diabetes and Its Complications
Auteur(s)
Le Boudec J., Marques-Vidal P., Cornuz J., Clair C.
ISSN
1873-460X (Electronic)
ISSN-L
1056-8727
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
30
Numéro
1
Pages
43-48
Langue
anglais
Résumé
AIMS: Smoking cessation has been suggested to increase the short-term risk of type 2 diabetes mellitus (T2DM). This study aimed at assessing the association between smoking cessation and incidence of T2DM and impaired fasting glucose (IFG).
METHODS: Data from participants in the CoLaus study, Switzerland, aged 35-75 at baseline and followed for 5.5years were used. Participants were classified as smokers, recent (≤5years), long-term (>5years) quitters, and non-smokers at baseline. Outcomes were IFG (fasting serum glucose (FSG) 5.6-6.99mmol/l) and T2DM (FSG ≥7.0mmol/l and/or treatment) at follow up.
RESULTS: 3,166 participants (63% women) had normal baseline FSG, of whom 26.7% were smokers, 6.5% recent quitters, and 23.5% long-term quitters. During follow-up 1,311 participants (41.4%) developed IFG (33.6% women, 54.7% men) and 47 (1.5%) developed T2DM (1.1% women, 2.1% men). Former smokers did not have statistically significant increased odds of IFG compared with smokers after adjustment for age, education, physical activity, hypercholesterolemia, hypertension and alcohol intake, with OR of 1.29 [95% confidence interval 0.94-1.76] for recent quitters and 1.03 [0.84-1.27] for long-term quitters. Former smokers did not have significant increased odds of T2DM compared with smokers with multivariable-adjusted OR of 1.53 [0.58-4.00] for recent quitters and 0.64 [0.27-1.48] for long-term quitters. Adjustment for body-mass index and waist circumference attenuated the association between recent quitting and IFG (OR 1.07 [0.78-1.48]) and T2DM (OR 1.28 [0.48-3.40].
CONCLUSION: In this middle-aged population, smoking cessation was not associated with an increased risk of IFG or T2DM.
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/02/2016 22:20
Dernière modification de la notice
20/08/2019 16:10
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