Injectability of silicone oil-based tamponade agents.

Details

Serval ID
serval:BIB_E71B9A90459A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Injectability of silicone oil-based tamponade agents.
Journal
The British journal of ophthalmology
Author(s)
Williams R.L., Day M.J., Garvey M.J., Morphis G., Irigoyen C., Wong D., Stappler T.
ISSN
1468-2079 (Electronic)
ISSN-L
0007-1161
Publication state
Published
Issued date
02/2011
Peer-reviewed
Oui
Volume
95
Number
2
Pages
273-276
Language
english
Notes
Publication types: Evaluation Studies ; Journal Article
Publication Status: ppublish
Abstract
High viscosity silicone oils are used as tamponade agents to increase the resistance to emulsification; however, this makes the oils more difficult to inject. Increasing the extensional viscosity is one way to reduce emulsification. This study aimed to evaluate how silicone oils with increased extensional viscosity behave in terms of their ease of injection.
The shear viscosity and the length of time taken to inject 9 ml of Siluron 1000, Siluron 2000, Siluron 5000, SiliconMate, a 56/44 w/w blend of Siluron 1000/Siluron 5000 (Blend A) and a 90/10 w/w blend of Siluron 1000/PDMS 423kDa molecular weight (Blend B) were examined.
The shear viscosity of Siluron 1000, Siluron 2000 and Siluron 5000 were within the expected ranges. The shear viscosity of Blend A was 2283 mPa s, Blend B was 4710 mPa s and SiliconMate was 995.3 mPa s. Siluron 1000 and SiliconMate had the shortest injection times as expected due to their lower shear viscosities. Comparison of Siluron 2000 and Blend A demonstrated that Siluron 2000 was easier to inject. Similarly, Blend B was easier to inject than Siluron 5000.
Silicone oil blends containing small percentages of a high molecular weight additive are easier to inject than single grade oils of the equivalent shear viscosity.
Keywords
Emulsions, Humans, Injections, Intraocular/instrumentation, Molecular Weight, Silicone Oils/administration & dosage, Silicone Oils/chemistry, Viscosity
Pubmed
Web of science
Create date
30/08/2018 15:56
Last modification date
20/08/2019 17:10
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