100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB.

Détails

Ressource 1Télécharger: fumagalli_bmcgen.pdf (1779.21 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_E6E1F47DF997
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB.
Périodique
BMC Genomics
Auteur(s)
Goebel J., Promerová M., Bonadonna F., McCoy K.D., Serbielle C., Strandh M., Yannic G., Burri R., Fumagalli L.
ISSN
1471-2164 (Electronic)
ISSN-L
1471-2164
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
18
Numéro
1
Pages
460
Langue
anglais
Résumé
Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds.
Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history.
Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.

Mots-clé
Biotechnology, Genetics, Birds, Birth-death evolution, Concerted evolution, Gene conversion, Gene duplication, Major histocompatibility complex, Recombination
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/06/2017 17:35
Dernière modification de la notice
09/05/2019 2:44
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