European genetic diversity and susceptibility to pathogens.

Details

Serval ID
serval:BIB_E673562BD973
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
European genetic diversity and susceptibility to pathogens.
Journal
Human Heredity
Author(s)
McLaren P.J., Fellay J., Telenti A.
ISSN
1423-0062 (Electronic)
ISSN-L
0001-5652
Publication state
Published
Issued date
2013
Volume
76
Number
3-4
Pages
187-193
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Infectious diseases, both in their endemic and epidemic forms, have shaped the human genome. Ecology has also contributed to geographically constrained pressures on human populations. There are now multiple examples of population-specific genetic variants that modulate susceptibility to infection - several of which have been observed solely in Europeans. The pathogen genome also mutates and adapts to individuals and common alleles in populations. The current understanding has benefited from genome-wide association studies as well as from rapid progress in the genetic characterization of Mendelian immunodeficiencies that are defined by susceptibility to specific pathogens. It is expected that current efforts to characterize rare human genetic variants will contribute to the understanding of severe manifestations of common infections in European and other human groups.
Pubmed
Web of science
Open Access
Yes
Create date
20/06/2014 17:44
Last modification date
20/08/2019 16:09
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