Effects of short-term carbohydrate or fat overfeeding on energy expenditure and plasma leptin concentrations in healthy female subjects

Details

Serval ID
serval:BIB_E66854F955A3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of short-term carbohydrate or fat overfeeding on energy expenditure and plasma leptin concentrations in healthy female subjects
Journal
International Journal of Obesity and Related Metabolic Disorders
Author(s)
Dirlewanger  M., di Vetta  V., Guenat  E., Battilana  P., Seematter  G., Schneiter  P., Jequier  E., Tappy  L.
ISSN
0307-0565 (Print)
Publication state
Published
Issued date
11/2000
Volume
24
Number
11
Pages
1413-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
OBJECTIVE: To determine the effects of excess carbohydrate or fat intake on plasma leptin concentrations and energy expenditure. DESIGN: Ten healthy lean females were studied: (a) during a 3 day isoenergetic diet (ISO); (b) during 3 day carbohydrate overfeeding (CHO OF); and (c) during 3 day fat overfeeding (FAT OF). During each test, basal metabolic rate, the energy expended during mild physical activity and recovery, and 24 h energy expenditure (24 h EE) were measured with indirect calorimetry. The concentrations of glucose and lactate were monitored in subcutaneous interstitial fluid over a 24 h period using microdialysis. Plasma hormone and substrate concentrations were measured in a blood sample collected in the morning of the fourth day. RESULTS: CHO OF increased plasma leptin concentrations by 28%, and 24 h EE by 7%. Basal metabolic rate and the energy expended during physical activity were not affected. FAT OF did not significantly change plasma leptin concentrations or energy expenditure. There was no relationship between changes in leptin concentrations and changes in energy expenditure, suggesting that leptin is not involved in the stimulation of energy metabolism during overfeeding. Interstitial subcutaneous glucose and lactate concentrations were not altered by CHO OF and FAT OF. CONCLUSIONS: CHO OF, but not FAT OF, increases energy expenditure and leptin concentration.
Keywords
3-Hydroxybutyric Acid/blood Adipose Tissue/chemistry Adult Basal Metabolism Calorimetry, Indirect Dietary Carbohydrates/*administration & dosage Dietary Fats/*administration & dosage *Eating Energy Metabolism/*physiology Exercise Extracellular Space/chemistry Fatty Acids, Nonesterified/blood Female Glucose/analysis Humans Lactates/analysis Leptin/*blood Microdialysis Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:36
Last modification date
20/08/2019 16:09
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