Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Bistability, epigenetics, and bet-hedging in bacteria.
Annual Review of Microbiology
Clonal populations of microbial cells often show a high degree of phenotypic variability under homogeneous conditions. Stochastic fluctuations in the cellular components that determine cellular states can cause two distinct subpopulations, a property called bistability. Phenotypic heterogeneity can be readily obtained by interlinking multiple gene regulatory pathways, effectively resulting in a genetic logic-AND gate. Although switching between states can occur within the cells' lifetime, cells can also pass their cellular state over to the next generation by a mechanism known as epigenetic inheritance and thus perpetuate the phenotypic state. Importantly, heterogeneous populations can demonstrate increased fitness compared with homogeneous populations. This suggests that microbial cells employ bet-hedging strategies to maximize survival. Here, we discuss the possible roles of interlinked bistable networks, epigenetic inheritance, and bet-hedging in bacteria.
Bacillus subtilis/genetics, Bacillus subtilis/physiology, Bacteria/genetics, Biofilms/growth & development, Biotechnology, Epigenesis, Genetic, Escherichia coli/genetics, Escherichia coli/physiology, Gene Regulatory Networks, Genomic Instability, Lac Operon, Models, Genetic, Phenotype, Spores, Bacterial/genetics, Transformation, Genetic
Web of science
Last modification date