Increased mortality after a first myocardial infarction in human immunodeficiency virus-infected patients; a nested cohort study.

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Serval ID
serval:BIB_E5C6BC3A4EDC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increased mortality after a first myocardial infarction in human immunodeficiency virus-infected patients; a nested cohort study.
Journal
Aids Research and Therapy
Author(s)
Carballo D., Delhumeau C., Carballo S., Bähler C., Radovanovic D., Hirschel B., Clerc O., Bernasconi E., Fasel D., Schmid P., Cusini A., Fehr J., Erne P., Keller P.F., Ledergerber B., Calmy A., AMIS registry
Working group(s)
Swiss HIV Cohort Study
Contributor(s)
AMIS registry
ISSN
1742-6405 (Electronic)
ISSN-L
1742-6405
Publication state
Published
Issued date
2015
Volume
12
Number
3
Pages
4
Language
english
Notes
Publication types: Journal Article
Abstract
AIMS: HIV infection may be associated with an increased recurrence rate of myocardial infarction. Our aim was to determine whether HIV infection is a risk factor for worse outcomes in patients with coronaray artery disease.
METHODS: We compared data aggregated from two ongoing cohorts: (i) the Acute Myocardial Infarction in Switzerland (AMIS) registry, which includes patients with acute myocardial infarction (AMI), and (ii) the Swiss HIV Cohort Study (SHCS), a prospective registry of HIV-positive (HIV+) patients. We included all patients who survived an incident AMI occurring on or after 1st January 2005. Our primary outcome measure was all-cause mortality at one year; secondary outcomes included AMI recurrence and cardiovascular-related hospitalisations. Comparisons used Cox and logistic regression analyses, respectively.
RESULTS: There were 133 HIV+, (SHCS) and 5,328 HIV-negative [HIV-] (AMIS) individuals with incident AMI. In the SHCS and AMIS registries, patients were predominantly male (72% and 85% male, respectively), with a median age of 51 years (interquartile range [IQR] 46-57) and 64 years (IQR 55-74), respectively. Nearly all (90%) of HIV+ individuals were on successful antiretroviral therapy. During the first year of follow-up, 5 (3.6%) HIV+ and 135 (2.5%) HIV- individuals died. At one year, HIV+ status after adjustment for age, sex, calendar year of AMI, smoking status, hypertension and diabetes was associated with a higher risk of death (HR 4.42, 95% CI 1.73-11.27). There were no significant differences in recurrent AMIs (4 [3.0%] HIV+ and 146 [3.0%] HIV- individuals, OR 1.16, 95% CI 0.41-3.27) or in hospitalization rates (OR 0.68 [95% CI 0.42-1.11]).
CONCLUSIONS: HIV infection was associated with a significantly increased risk of all-cause mortality one year after incident AMI.
Keywords
Agglutination Tests, Ampicillin/pharmacology, Animals, Epithelium/ultrastructure, Feeding Behavior, Rabbits, Tsetse Flies/microbiology, Tsetse Flies/ultrastructure
Pubmed
Web of science
Open Access
Yes
Create date
22/02/2015 9:37
Last modification date
20/08/2019 16:09
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