Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.

Ciriello, G.; Gatza, M.L.; Beck, A.H.; Wilkerson, M.D.; Rhie, S.K.; Pastore, A.; Zhang, H.; McLellan, M.; Yau, C.; Kandoth, C.; Bowlby, R.; Shen, H.; Hayat, S.; Fieldhouse, R.; Lester, S.C.; Tse, G.M.; Factor, R.E.; Collins, L.C.; Allison, K.H.; Chen, Y.Y.; Jensen, K.; Johnson, N.B.; Oesterreich, S.; Mills, G.B.; Cherniack, A.D.; Robertson, G.; Benz, C.; Sander, C.; Laird, P.W.; Hoadley, K.A.; King, T.A.; TCGA Research, Network; Perou, C.M.; Perou, C.M.

doi:10.1016/j.cell.2015.09.033

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.

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Serval ID

serval:BIB_E5BACAE80B12

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.

Journal

Cell

Author(s)

Ciriello G., Gatza M.L., Beck A.H., Wilkerson M.D., Rhie S.K., Pastore A., Zhang H., McLellan M., Yau C., Kandoth C., Bowlby R., Shen H., Hayat S., Fieldhouse R., Lester S.C., Tse G.M., Factor R.E., Collins L.C., Allison K.H., Chen Y.Y., Jensen K., Johnson N.B., Oesterreich S., Mills G.B., Cherniack A.D., Robertson G., Benz C., Sander C., Laird P.W., Hoadley K.A., King T.A., TCGA Research Network, Perou C.M., Perou C.M.

Contributor(s)

TCGA Research Network, Akbani R., Auman JT., Balasundaram M., Balu S., Barr T., Beck A., Benz C., Benz S., Berrios M., Beroukhim R., Bodenheimer T., Boice L., Bootwalla MS., Bowen J., Bowlby R., Brooks D., Cherniack AD., Chin L., Cho J., Chudamani S., Ciriello G., Davidsen T., Demchok JA., Dennison JB., Ding L., Felau I., Ferguson ML., Frazer S., Gabriel SB., Gao J., Gastier-Foster JM., Gatza ML., Gehlenborg N., Gerken M., Getz G., Gibson WJ., Hayes DN., Heiman DI., Hoadley KA., Holbrook A., Holt RA., Hoyle AP., Hu H., Huang M., Hutter CM., Hwang ES., Jefferys SR., Jones SJ., Ju Z., Kim J., Lai PH., Laird PW., Lawrence MS., Leraas KM., Lichtenberg TM., Lin P., Ling S., Liu J., Liu W., Lolla L., Lu Y., Ma Y., Maglinte DT., Mardis E., Marks J., Marra MA., McAllister C., McLellan M., Meng S., Meyerson M., Mills GB., Moore RA., Mose LE., Mungall AJ., Murray BA., Naresh R., Noble MS., Oesterreich S., Olopade O., Parker JS., Perou CM., Pihl T., Saksena G., Schumacher SE., Shaw KR., Ramirez NC., Rathmell WK., Rhie SK., Roach J., Robertson AG., Saksena G., Sander C., Schein JE., Schultz N., Shen H., Sheth M., Shi Y., Shih J., Shelley CS., Shriver C., Simons JV., Sofia HJ., Soloway MG., Sougnez C., Sun C., Tarnuzzer R., Tiezzi DG., Van Den Berg DJ. , Voet D., Wan Y., Wang Z., Weinstein JN., Weisenberger DJ., Wilkerson MD., Wilson R., Wise L., Wiznerowicz M., Wu J., Wu Y., Yang L., Yau C., Zack TI., Zenklusen JC., Zhang H., Zhang J., Zmuda E.

ISSN

1097-4172 (Electronic)

ISSN-L

0092-8674

Publication state

Published

Issued date

2015

Peer-reviewed

Oui

Volume

163

Number

Pages

506-519

Language

english

Notes

Publication types: Journal ArticlePublication Status: ppublish

Abstract

Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. Spatially clustered FOXA1 mutations correlated with increased FOXA1 expression and activity. Conversely, GATA3 mutations and high expression characterized luminal A IDC, suggesting differential modulation of ER activity in ILC and IDC. Proliferation and immune-related signatures determined three ILC transcriptional subtypes associated with survival differences. Mixed IDC/ILC cases were molecularly classified as ILC-like and IDC-like revealing no true hybrid features. This multidimensional molecular atlas sheds new light on the genetic bases of ILC and provides potential clinical options.

OAI-PMH

oai:serval.unil.ch:BIB_E5BACAE80B12

DOI

10.1016/j.cell.2015.09.033

Pubmed

26451490

Web of science

000362952700023

Open Access

Yes

Create date

09/11/2015 15:10