Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.

Détails

ID Serval
serval:BIB_E5BACAE80B12
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
Périodique
Cell
Auteur(s)
Ciriello G., Gatza M.L., Beck A.H., Wilkerson M.D., Rhie S.K., Pastore A., Zhang H., McLellan M., Yau C., Kandoth C., Bowlby R., Shen H., Hayat S., Fieldhouse R., Lester S.C., Tse G.M., Factor R.E., Collins L.C., Allison K.H., Chen Y.Y., Jensen K., Johnson N.B., Oesterreich S., Mills G.B., Cherniack A.D., Robertson G., Benz C., Sander C., Laird P.W., Hoadley K.A., King T.A., TCGA Research Network, Perou C.M., Perou C.M.
Contributeur(s)
TCGA Research Network, Akbani R., Auman JT., Balasundaram M., Balu S., Barr T., Beck A., Benz C., Benz S., Berrios M., Beroukhim R., Bodenheimer T., Boice L., Bootwalla MS., Bowen J., Bowlby R., Brooks D., Cherniack AD., Chin L., Cho J., Chudamani S., Ciriello G., Davidsen T., Demchok JA., Dennison JB., Ding L., Felau I., Ferguson ML., Frazer S., Gabriel SB., Gao J., Gastier-Foster JM., Gatza ML., Gehlenborg N., Gerken M., Getz G., Gibson WJ., Hayes DN., Heiman DI., Hoadley KA., Holbrook A., Holt RA., Hoyle AP., Hu H., Huang M., Hutter CM., Hwang ES., Jefferys SR., Jones SJ., Ju Z., Kim J., Lai PH., Laird PW., Lawrence MS., Leraas KM., Lichtenberg TM., Lin P., Ling S., Liu J., Liu W., Lolla L., Lu Y., Ma Y., Maglinte DT., Mardis E., Marks J., Marra MA., McAllister C., McLellan M., Meng S., Meyerson M., Mills GB., Moore RA., Mose LE., Mungall AJ., Murray BA., Naresh R., Noble MS., Oesterreich S., Olopade O., Parker JS., Perou CM., Pihl T., Saksena G., Schumacher SE., Shaw KR., Ramirez NC., Rathmell WK., Rhie SK., Roach J., Robertson AG., Saksena G., Sander C., Schein JE., Schultz N., Shen H., Sheth M., Shi Y., Shih J., Shelley CS., Shriver C., Simons JV., Sofia HJ., Soloway MG., Sougnez C., Sun C., Tarnuzzer R., Tiezzi DG., Van Den Berg DJ. , Voet D., Wan Y., Wang Z., Weinstein JN., Weisenberger DJ., Wilkerson MD., Wilson R., Wise L., Wiznerowicz M., Wu J., Wu Y., Yang L., Yau C., Zack TI., Zenklusen JC., Zhang H., Zhang J., Zmuda E.
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
163
Numéro
2
Pages
506-519
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. Spatially clustered FOXA1 mutations correlated with increased FOXA1 expression and activity. Conversely, GATA3 mutations and high expression characterized luminal A IDC, suggesting differential modulation of ER activity in ILC and IDC. Proliferation and immune-related signatures determined three ILC transcriptional subtypes associated with survival differences. Mixed IDC/ILC cases were molecularly classified as ILC-like and IDC-like revealing no true hybrid features. This multidimensional molecular atlas sheds new light on the genetic bases of ILC and provides potential clinical options.
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/11/2015 14:10
Dernière modification de la notice
20/08/2019 16:09
Données d'usage