Identical V beta T-cell receptor genes used in alloreactive cytotoxic and antigen plus I-A specific helper T cells.

Details

Serval ID
serval:BIB_E5B1BDF35B28
Type
Article: article from journal or magazin.
Collection
Publications
Title
Identical V beta T-cell receptor genes used in alloreactive cytotoxic and antigen plus I-A specific helper T cells.
Journal
Nature
Author(s)
Rupp F., Acha-Orbea H., Hengartner H., Zinkernagel R., Joho R.
ISSN
0028-0836 (Print)
ISSN-L
0028-0836
Publication state
Published
Issued date
1985
Volume
315
Number
6018
Pages
425-427
Language
english
Abstract
T lymphocytes involved in the cellular immune response carry cell-surface receptors responsible for antigen and self recognition. This T-cell receptor molecule is a heterodimeric protein consisting of disulphide-linked alpha- and beta-chains with variable (V) and constant (C) regions. Several complementary DNA and genomic DNA clones have been isolated and characterized. These analyses showed that the genomic arrangement and rearrangement of T-cell receptor genes using VT, diversity (DT), joining (JT) and CT gene segments is very similar to the structure of the known immunoglobulin genes. We have isolated two cDNA clones from an allospecific cytotoxic T cell, one of which shows a productive V beta-J beta-C beta 1 rearrangement without an intervening D beta segment. This V beta gene segment is identical to the V beta gene expressed in a helper T-cell clone specific for chicken red blood cells and H-21. The other clone carries the C beta 2 gene of the T-cell receptor, but the C beta 2 sequence is preceded by a DNA sequence that does not show any similarity to V beta or J beta sequences.
Keywords
Animals, Base Sequence, Epitopes, Erythrocytes/immunology, Genes, Histocompatibility Antigens Class II, Immunoglobulin Variable Region/genetics, Mice, Receptors, Antigen, T-Cell/genetics, T-Lymphocytes/physiology, T-Lymphocytes, Cytotoxic/physiology, T-Lymphocytes, Helper-Inducer/physiology
Pubmed
Web of science
Create date
24/01/2008 14:47
Last modification date
20/08/2019 16:09
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