Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_E57FF1F50B45
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds.
Périodique
Age
Auteur(s)
Delhaye J., Salamin N., Roulin A., Criscuolo F., Bize P., Christe P.
ISSN
1574-4647 (Electronic)
ISSN-L
0161-9152
Statut éditorial
Publié
Date de publication
12/2016
Peer-reviewed
Oui
Volume
38
Numéro
5-6
Pages
433-443
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Mitochondrial respiration releases reactive oxygen species (ROS) as by-products that can damage the soma and may in turn accelerate ageing. Hence, according to "the oxidative stress theory of ageing", longer-lived organisms may have evolved mechanisms that improve mitochondrial function, reduce ROS production and/or increase cell resistance to oxidative damage. Cardiolipin, an important mitochondrial inner-membrane phospholipid, has these properties by binding and stabilizing mitochondrial inner-membrane proteins. Here, we investigated whether ROS production, cardiolipin content and cell membrane resistance to oxidative attack in freshly collected red blood cells (RBCs) are associated with longevity (range 5-35 years) in 21 bird species belonging to seven Orders. After controlling for phylogeny, body size and oxygen consumption, variation in maximum longevity was significantly explained by mitochondrial ROS production and cardiolipin content, but not by membrane resistance to oxidative attack. RBCs of longer-lived species produced less ROS and contained more cardiolipin than RBCs of shorter-lived species did. These results support the oxidative stress theory of ageing and shed light on mitochondrial cardiolipin as an important factor linking ROS production to longevity.

Mots-clé
Aging/metabolism, Animals, Birds/blood, Birds/metabolism, Body Weight, Cardiolipins/analysis, Cardiolipins/metabolism, Erythrocytes/chemistry, Erythrocytes/metabolism, Longevity, Mitochondria/metabolism, Mitochondrial Membranes/chemistry, Oxidative Stress, Oxygen Consumption, Phylogeny, Reactive Oxygen Species/analysis, Reactive Oxygen Species/chemistry, Birds, Comparative methods, Free radicals, Phospholipids
Pubmed
Web of science
Création de la notice
12/01/2017 12:46
Dernière modification de la notice
20/08/2019 16:08
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