The type III secretion system tip complex and translocon.

Détails

ID Serval
serval:BIB_E55332556FF5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The type III secretion system tip complex and translocon.
Périodique
Molecular Microbiology
Auteur(s)
Mueller C.A., Broz P., Cornelis G.R.
ISSN
1365-2958 (Electronic)
ISSN-L
0950-382X
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
68
Numéro
5
Pages
1085-1095
Langue
anglais
Résumé
The type III secretion machinery of Gram-negative bacteria, also known as the injectisome or needle complex, is composed of a basal body spanning both bacterial membranes and the periplasm, and an external needle protruding from the bacterial surface. A set of three proteins, two hydrophobic and one hydrophilic, are required to allow translocation of proteins from the bacterium to the host cell cytoplasm. These proteins are involved in the formation of a translocation pore, the translocon, in the host cell membrane. Exciting progress has recently been made on the interaction between the translocators and the injectisome needle and the assembly of the translocon in the host cell membrane. As expected, the two hydrophobic translocators insert into the target cell membrane. Unexpectedly, the third, hydrophilic translocator, forms a complex on the distal end of the injectisome needle, the tip complex, and serves as an assembly platform for the two hydrophobic translocators.

Mots-clé
Antigens, Bacterial/genetics, Antigens, Bacterial/physiology, Bacterial Proteins/genetics, Bacterial Proteins/isolation & purification, Bacterial Proteins/metabolism, Bacterial Proteins/secretion, Biological Transport, Cytoplasm/metabolism, Gram-Negative Bacteria/genetics, Gram-Negative Bacteria/pathogenicity, Membrane Proteins/metabolism, Pore Forming Cytotoxic Proteins
Pubmed
Web of science
Création de la notice
25/10/2017 11:05
Dernière modification de la notice
20/08/2019 17:08
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