Mapping the human connectome at multiple scales with diffusion spectrum MRI.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_E51C98BC165A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mapping the human connectome at multiple scales with diffusion spectrum MRI.
Périodique
Journal of Neuroscience Methods
Auteur(s)
Cammoun L., Gigandet X., Meskaldji D., Thiran J.P., Sporns O., Do K.Q., Maeder P., Meuli R., Hagmann P.
ISSN
1872-678X (Electronic)
ISSN-L
0165-0270
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
203
Numéro
2
Pages
386-397
Langue
anglais
Résumé
The global structural connectivity of the brain, the human connectome, is now accessible at millimeter scale with the use of MRI. In this paper, we describe an approach to map the connectome by constructing normalized whole-brain structural connection matrices derived from diffusion MRI tractography at 5 different scales. Using a template-based approach to match cortical landmarks of different subjects, we propose a robust method that allows (a) the selection of identical cortical regions of interest of desired size and location in different subjects with identification of the associated fiber tracts (b) straightforward construction and interpretation of anatomically organized whole-brain connection matrices and (c) statistical inter-subject comparison of brain connectivity at various scales. The fully automated post-processing steps necessary to build such matrices are detailed in this paper. Extensive validation tests are performed to assess the reproducibility of the method in a group of 5 healthy subjects and its reliability is as well considerably discussed in a group of 20 healthy subjects.
Pubmed
Web of science
Création de la notice
24/10/2011 15:22
Dernière modification de la notice
20/08/2019 16:08
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