Acinar cell carcinoma of the pancreas with thyroid-like follicular features: first description of a new diagnostic challenging subtype.

Détails

Ressource 1Demande d'une copie Sous embargo jusqu'au 07/08/2020.
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_E4D0E1AAA380
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Acinar cell carcinoma of the pancreas with thyroid-like follicular features: first description of a new diagnostic challenging subtype.
Périodique
Virchows Archiv
Auteur(s)
Saglietti C., Schneider V., Bongiovanni M., Missiaglia E., Bisig B., Dorta G., Demartines N., Sempoux C., La Rosa S.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Statut éditorial
Publié
Date de publication
12/2019
Peer-reviewed
Oui
Volume
475
Numéro
6
Pages
789-794
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
Acinar cell carcinomas (ACCs) of the pancreas are a heterogeneous group of neoplasms showing a wide spectrum of morphological features including acinar, solid, glandular, and trabecular architecture. In addition, uncommon cytological aspects have recently been described and include oncocytic, spindle, clear, and pleomorphic cell types. This wide histological spectrum represents a challenge in the diagnostic task for pathologists. Molecular mechanisms involved in the onset and progression of ACCs are not completely known, but, in general, they differ from those observed in ductal adenocarcinomas or neuroendocrine neoplasms of the pancreas and frequently include alterations in the APC/β-catenin pathway. In the present paper, we describe a new variant of ACC showing thyroid-like follicular features and CTNNB1 mutation. This phenotype needs to be included in the spectrum of morphological presentation of ACC.
Mots-clé
Carcinoma, Acinar Cell/diagnosis, Carcinoma, Acinar Cell/genetics, Carcinoma, Acinar Cell/pathology, Diagnosis, Differential, Humans, Male, Middle Aged, Mutation/genetics, Pancreatic Neoplasms/diagnosis, Pancreatic Neoplasms/pathology, Thyroid Gland/pathology, beta Catenin/genetics, beta Catenin/metabolism, Acinar cell carcinoma, Differential diagnosis, Morphology, Pancreas, Thyroid-like
Pubmed
Web of science
Création de la notice
26/07/2019 13:36
Dernière modification de la notice
04/01/2020 6:17
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