Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells.

Details

Serval ID
serval:BIB_E4C51DCAD9B2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells.
Journal
Immunity
Author(s)
Wang Y.H., Ito T., Wang Y.H., Homey B., Watanabe N., Martin R., Barnes C.J., McIntyre B.W., Gilliet M., Kumar R., Yao Z., Liu Y.J.
ISSN
1074-7613 (Print)
ISSN-L
1074-7613
Publication state
Published
Issued date
2006
Volume
24
Number
6
Pages
827-838
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The identity of TH2 memory cells and the mechanism regulating their maintenance during allergic inflammation remain elusive. We report that circulated human CD4+ T cells expressing the prostaglandin D2 receptor (CRTH2) are TH2 central memory T cells, characterized by their phenotype, TH2 cytokine production, gene-expression profile, and the ability to respond to allergens. Only dendritic cells (DCs) activated by thymic stromal lymphopoietin (TSLP) can induce a robust expansion of CRTH2+CD4+ TH2 memory cells, while maintaining their central memory phenotype and TH2 commitments. CRTH2+CD4+ TH2 memory cells activated by TSLP-DCs undergo further TH2 polarization and express cystatin A, Charcot-Leydon crystal protein, and prostaglandin D2 synthase, implying their broader roles in allergic inflammation. Infiltrated CRTH2+CD4+ TH2 effector memory T cells in skin lesion of atopic dermatitis were associated with activated DCs, suggesting that TSLP-DCs play important roles not only in TH2 priming, but also in the maintenance and further polarization of TH2 central memory cells in allergic diseases.
Keywords
Antigens, Differentiation/metabolism, Cell Polarity/genetics, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor Proteins/genetics, Cyclin-Dependent Kinase Inhibitor Proteins/metabolism, Cystatins/genetics, Cytokines/genetics, Cytokines/pharmacology, Dendritic Cells/drug effects, Dendritic Cells/immunology, Dermatitis, Atopic/genetics, Dermatitis, Atopic/immunology, Gene Expression Profiling, Glycoproteins/genetics, Humans, Immunologic Memory/genetics, Intramolecular Oxidoreductases/genetics, Lipocalins, Lymphocyte Activation/genetics, Lysophospholipase/genetics, Membrane Glycoproteins/metabolism, OX40 Ligand, Receptors, Immunologic/analysis, Receptors, Immunologic/metabolism, Receptors, Prostaglandin/analysis, Receptors, Prostaglandin/metabolism, Th2 Cells/immunology, Tumor Necrosis Factors/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2012 18:47
Last modification date
20/08/2019 16:08
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