Alternate gas washout indices: Assessment of ventilation inhomogeneity in mild to moderate pediatric cystic fibrosis lung disease.
Details
Serval ID
serval:BIB_E4A0A66D4535
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Alternate gas washout indices: Assessment of ventilation inhomogeneity in mild to moderate pediatric cystic fibrosis lung disease.
Journal
Pediatric pulmonology
ISSN
1099-0496 (Electronic)
ISSN-L
1099-0496
Publication state
Published
Issued date
11/2018
Peer-reviewed
Oui
Volume
53
Number
11
Pages
1485-1491
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Normalized phase III slope (Sn <sub>III</sub> ) indices from multiple breath washout (MBW) estimate ventilation inhomogeneity. Alternate (*) protocols for Sn <sub>III</sub> indices exist, however the utility of these outcomes in children with mild-to-moderate cystic fibrosis (CF) is unknown.
We measured nitrogen MBW and spirometry in 135 children (43 controls) aged 4-18 years. We assessed validity, practicability, and reliability of Sn <sub>III</sub> protocols. Outcomes included the ability to detect abnormal lung function, test agreement, measurement duration, intra-test repeatability, and quality.
Lung clearance index (LCI) was abnormal in 80 (87%), Scond in 55 (60%), Scond* in 17 (19%), Sacin in 10 (11%), Sacin* in 11 (12%), and FEV <sub>1</sub> in 28 (30%). Alternate protocols reduced measurement duration. Agreement of indices to detect abnormal lung function was poor. The quality of analysis and repeatability deteriorated with the alternate technique compared to standard.
In children with mild-to-moderate CF lung disease, alternate protocols seem practical but clinimetric properties of standard Sn <sub>III</sub> protocols are preferable.
We measured nitrogen MBW and spirometry in 135 children (43 controls) aged 4-18 years. We assessed validity, practicability, and reliability of Sn <sub>III</sub> protocols. Outcomes included the ability to detect abnormal lung function, test agreement, measurement duration, intra-test repeatability, and quality.
Lung clearance index (LCI) was abnormal in 80 (87%), Scond in 55 (60%), Scond* in 17 (19%), Sacin in 10 (11%), Sacin* in 11 (12%), and FEV <sub>1</sub> in 28 (30%). Alternate protocols reduced measurement duration. Agreement of indices to detect abnormal lung function was poor. The quality of analysis and repeatability deteriorated with the alternate technique compared to standard.
In children with mild-to-moderate CF lung disease, alternate protocols seem practical but clinimetric properties of standard Sn <sub>III</sub> protocols are preferable.
Keywords
child, cystic fibrosis, lung function tests
Pubmed
Web of science
Create date
03/09/2018 11:40
Last modification date
20/08/2019 16:08
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