Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Modulation of cardiac function by A-kinase anchoring proteins.
Current Opinion in Pharmacology
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
The cAMP-dependent kinase (PKA) is a broad specificity kinase that controls several fundamental processes in the heart including the strength and the frequency of contraction, the duration of the cardiac action potential as well as the activation of signaling pathways associated with the onset of cardiac hypertrophy and heart failure. It is now appreciated that to perform these functions, PKA must be precisely targeted in proximity to its cellular substrates. Evidence collected over the last years demonstrates that compartmentalization of the kinase is achieved through the association with A-kinase anchoring proteins (AKAPs). This family of functionally related proteins organize multivalent signaling complexes that target PKA and other signaling enzymes at precise subcellular sites within cardiomyocytes where they can be accessed by activators and, in turn, phosphorylate and modulate particular substrates.
A Kinase Anchor Proteins/physiology, Action Potentials/physiology, Animals, Calcium/metabolism, Cardiomegaly/drug therapy, Cardiomegaly/physiopathology, Cyclic AMP-Dependent Protein Kinases/physiology, Drug Delivery Systems, Heart Failure/drug therapy, Heart Failure/physiopathology, Humans, Myocardial Contraction/physiology, Signal Transduction
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