Sex-chromosome turnovers induced by deleterious mutation load.

Détails

ID Serval
serval:BIB_E41CACA16176
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sex-chromosome turnovers induced by deleterious mutation load.
Périodique
Evolution
Auteur(s)
Blaser O., Grossen C., Neuenschwander S., Perrin N.
ISSN
1558-5646 (Electronic)
ISSN-L
0014-3820
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
67
Numéro
3
Pages
635-645
Langue
anglais
Résumé
In sharp contrast with mammals and birds, many cold-blooded vertebrates present homomorphic sex chromosomes. Empirical evidence supports a role for frequent turnovers, which replace nonrecombining sex chromosomes before they have time to decay. Three main mechanisms have been proposed for such turnovers, relying either on neutral processes, sex-ratio selection, or intrinsic benefits of the new sex-determining genes (due, e.g., to linkage with sexually antagonistic mutations). Here, we suggest an additional mechanism, arising from the load of deleterious mutations that accumulate on nonrecombining sex chromosomes. In the absence of dosage compensation, this load should progressively lower survival rate in the heterogametic sex. Turnovers should occur when this cost outweighs the benefits gained from any sexually antagonistic genes carried by the nonrecombining sex chromosome. We use individual-based simulations of a Muller's ratchet process to test this prediction, and investigate how the relevant parameters (effective population size, strength and dominance of deleterious mutations, size of nonrecombining segment, and strength of sexually antagonistic selection) are expected to affect the rate of turnovers.
Mots-clé
Dosage compensation, recombination, sex-antagonistic genes, sex-chromosome decay, sex determination
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/09/2012 7:01
Dernière modification de la notice
09/05/2019 2:36
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