Neuropathy, amyloidosis, and monoclonal gammopathy

Details

Serval ID
serval:BIB_E3FEB9460469
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neuropathy, amyloidosis, and monoclonal gammopathy
Journal
Journal of Neurology, Neurosurgery and Psychiatry
Author(s)
Fitting  J. W., Bischoff  A., Regli  F., De Crousaz  G.
ISSN
0022-3050 (Print)
Publication state
Published
Issued date
03/1979
Volume
42
Number
3
Pages
193-202
Notes
Journal Article --- Old month value: Mar
Abstract
Three cases of neuropathy with monoclonal gammopathy and amyloid deposits in peripheral nerves are described. They appeared to present a benign gammopathy because of the duration of the neuropathy in the absence of any clinical or biological sign of myeloma or macroglobulinaemia. The pathological abnormality found in the sural nerves of the three patients was characterised by a marked loss of myelinated and unmyelinated nerve fibres because of active axonal degeneration with Wallerian degeneration. The most striking feature in all three cases was the finding of deposits identified as an accumulation of microfibrils.
Keywords
Aged Amyloidosis/*complications/pathology Cytoskeleton/ultrastructure Humans Hypergammaglobulinemia/*complications/pathology Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains Male Microscopy, Electron Middle Aged Peripheral Nerves/ultrastructure Peripheral Nervous System Diseases/*complications/pathology Sural Nerve/ultrastructure
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 9:43
Last modification date
20/08/2019 16:07
Usage data