Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials
Details
Serval ID
serval:BIB_E34DABEF544D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials
Journal
Diabet Med
Working group(s)
Gragil group
ISSN
1464-5491 (Electronic)
ISSN-L
0742-3071
Publication state
Published
Issued date
06/2009
Volume
26
Number
6
Pages
617-21
Language
english
Notes
Benhamou, P Y
Milliat-Guittard, L
Wojtusciszyn, A
Kessler, L
Toso, C
Baertschiger, R
Debaty, I
Badet, L
Penfornis, A
Thivolet, C
Renard, E
Bayle, F
Morel, P
Morelon, E
Colin, C
Berney, T
eng
Research Support, Non-U.S. Gov't
England
Diabet Med. 2009 Jun;26(6):617-21. doi: 10.1111/j.1464-5491.2009.02731.x.
Milliat-Guittard, L
Wojtusciszyn, A
Kessler, L
Toso, C
Baertschiger, R
Debaty, I
Badet, L
Penfornis, A
Thivolet, C
Renard, E
Bayle, F
Morel, P
Morelon, E
Colin, C
Berney, T
eng
Research Support, Non-U.S. Gov't
England
Diabet Med. 2009 Jun;26(6):617-21. doi: 10.1111/j.1464-5491.2009.02731.x.
Abstract
BACKGROUND: Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation. METHODS: The 36-Item Short Form Health Survey (SF-36) and the Diabetes Quality of Life (DQOL) scales were completed by patients included in an Islet Transplantation Alone (ITA) trial (n = 10) and an Islet After Kidney (IAK) trial (n = 10). RESULTS: The two populations differed by HRQL scores at baseline, with poorer scores in ITA patients. SF-36 scores for physical limitations, bodily pain, general health perception, social functioning, and health transition improved significantly in ITA patients 6 and 12 months post transplantation. The DQOL global score was significantly improved at 6 months and remained so at 12 months, because of a significant improvement in the dimensions of satisfaction and impact of diabetes. No improvement was observed in the IAK patients. CONCLUSION: HRQL assessment may help in the selection of candidates with brittle diabetes for islet transplantation.
Keywords
Clinical Trials as Topic, Diabetes Mellitus, Type 1/*surgery, Female, Humans, *Islets of Langerhans Transplantation, Male, Middle Aged, *Quality of Life, Treatment Outcome
Pubmed
Create date
14/06/2021 9:58
Last modification date
18/09/2021 6:38