What to compare and how: Comparative transcriptomics for Evo-Devo.

Détails

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Etat: Serval
Version: Final published version
ID Serval
serval:BIB_E322E5E2A13A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
What to compare and how: Comparative transcriptomics for Evo-Devo.
Périodique
Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
Auteur(s)
Roux J., Rosikiewicz M., Robinson-Rechavi M.
ISSN
1552-5015 (Electronic)
ISSN-L
1552-5007
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
324
Numéro
4
Pages
372-382
Langue
anglais
Résumé
Evolutionary developmental biology has grown historically from the capacity to relate patterns of evolution in anatomy to patterns of evolution of expression of specific genes, whether between very distantly related species, or very closely related species or populations. Scaling up such studies by taking advantage of modern transcriptomics brings promising improvements, allowing us to estimate the overall impact and molecular mechanisms of convergence, constraint or innovation in anatomy and development. But it also presents major challenges, including the computational definitions of anatomical homology and of organ function, the criteria for the comparison of developmental stages, the annotation of transcriptomics data to proper anatomical and developmental terms, and the statistical methods to compare transcriptomic data between species to highlight significant conservation or changes. In this article, we review these challenges, and the ongoing efforts to address them, which are emerging from bioinformatics work on ontologies, evolutionary statistics, and data curation, with a focus on their implementation in the context of the development of our database Bgee (http://bgee.org). J. Exp. Zool. (Mol. Dev. Evol.) 324B: 372-382, 2015. © 2015 Wiley Periodicals, Inc.
Pubmed
Web of science
Création de la notice
20/02/2015 10:11
Dernière modification de la notice
03/03/2018 22:11
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