Language processing within the striatum: evidence from a PET correlation study in Huntington's disease.

Détails

ID Serval
serval:BIB_E2C65D1994B7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Language processing within the striatum: evidence from a PET correlation study in Huntington's disease.
Périodique
Brain
Auteur(s)
Teichmann M., Gaura V., Démonet J.F., Supiot F., Delliaux M., Verny C., Renou P., Remy P., Bachoud-Lévi A.C.
ISSN
1460-2156 (Electronic)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
131
Numéro
Pt 4
Pages
1046-1056
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The role of sub-cortical structures in language processing, and more specifically of the striatum, remains controversial. In line with psycholinguistic models stating that language processing implies both the recovery of lexical information and the application of combinatorial rules, the striatum has been claimed to be involved either in the former component or in the latter. The present study reconciles these conflicting views by showing the striatum's involvement in both language processes, depending on distinct striatal sub-regions. Using PET scanning in a model of striatal disorders, namely Huntington's disease (HD), we correlated metabolic data of 31 early stage HD patients regarding different striatal sub-regions with behavioural scores on three rule/lexicon tasks drawn from word morphology, syntax and from a non-linguistic domain, namely arithmetic. Behavioural results reflected impairment on both processing aspects, while deficits predominated on rule application. Both correlated with the left striatum but involved distinct striatal sub-regions. We suggest that the left striatum encompasses linguistic and arithmetic circuits, which differ with respect to their anatomical and functional specification, comprising ventrally located regions dedicated to rule computations and more dorsal portions pertaining to lexical devices.
Mots-clé
Adult, Brain Mapping/methods, Comprehension, Corpus Striatum/physiopathology, Corpus Striatum/radionuclide imaging, Female, Humans, Huntington Disease/physiopathology, Huntington Disease/psychology, Image Interpretation, Computer-Assisted/methods, Language, Language Tests, Male, Mathematics, Middle Aged, Positron-Emission Tomography
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/03/2013 20:01
Dernière modification de la notice
09/05/2019 2:31
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