Article: article from journal or magazin.
Childhood and malaria vaccines combined in biodegradable microspheres produce immunity with synergistic interactions.
Journal of Controlled Release
Biodegradable microspheres may represent a potential tool for the delivery of combination vaccines. We demonstrate strong immunogenicity of five co-encapsulated antigens after a single subcutaneous inoculation in guinea pigs. Tetanus- and diphtheria-specific antibodies were not significantly affected by the presence of either antigen or by the presence of pertussis or Haemophilus influenzae type b (Hib) antigens. Microsphere formulations gave better protection against diphtheria toxin than did two injections of a licensed tetravalent vaccine. Finally, a synthetic malaria peptide antigen (PfCS) also encapsulated in PLGA microspheres increased diphtheria and tetanus-specific immunity and improved protection against diphtheria. These findings demonstrate the potential of microspheres as an alternative and promising strategy for combination vaccines with a further aptitude in reducing the number of inoculations required to gain functional immunity.
Animals, Antibodies, Bacterial, Antibody Specificity, Antigens, Bacterial, Biodegradation, Environmental, Diphtheria Toxin, Drug Evaluation, Preclinical, Female, Guinea Pigs, Haemophilus influenzae type b, Humans, Immunization, Infant, Injections, Subcutaneous, Lactic Acid, Malaria Vaccines, Mice, Microspheres, Neutralization Tests, Peptides, Plasmodium falciparum, Polyglycolic Acid, Polymers, Vaccines, Combined, Vaccines, Synthetic
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