Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.

Czamara, D.; Eraslan, G.; Page, C.M.; Lahti, J.; Lahti-Pulkkinen, M.; Hämäläinen, E.; Kajantie, E.; Laivuori, H.; Villa, P.M.; Reynolds, R.M.; Nystad, W.; Håberg, S.E.; London, S.J.; O'Donnell, K.J.; Garg, E.; Meaney, M.J.; Entringer, S.; Wadhwa, P.D.; Buss, C.; Jones, M.J.; Lin, DTS; MacIsaac, J.L.; Kobor, M.S.; Koen, N.; Zar, H.J.; Koenen, K.C.; Dalvie, S.; Stein, D.J.; Kondofersky, I.; Müller, N.S.; Theis, F.J.; Räikkönen, K.; Binder, E.B.

doi:10.1038/s41467-019-10461-0

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.

Details

Download: 31186427.pdf (1085.44 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_E27A7F7B67AB

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.

Journal

Nature communications

Author(s)

Czamara D., Eraslan G., Page C.M., Lahti J., Lahti-Pulkkinen M., Hämäläinen E., Kajantie E., Laivuori H., Villa P.M., Reynolds R.M., Nystad W., Håberg S.E., London S.J., O'Donnell K.J., Garg E., Meaney M.J., Entringer S., Wadhwa P.D., Buss C., Jones M.J., Lin DTS, MacIsaac J.L., Kobor M.S., Koen N., Zar H.J., Koenen K.C., Dalvie S., Stein D.J., Kondofersky I., Müller N.S., Theis F.J., Räikkönen K., Binder E.B.

Working group(s)

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

Contributor(s)

Wray N.R., Ripke S., Mattheisen M., Trzaskowski M., Byrne E.M., Abdellaoui A., Adams M.J., Agerbo E., Air T.M., Andlauer TFM, Bacanu S.A., Bækvad-Hansen M., Beekman ATF, Bigdeli T.B., Blackwood DHR, Bryois J., Buttenschøn H.N., Bybjerg-Grauholm J., Cai N., Castelao E., Christensen J.H., Clarke T.K., Coleman JRI, Colodro-Conde L., Couvy-Duchesne B., Craddock N., Crawford G.E., Davies G., Deary I.J., Degenhardt F., Derks E.M., Direk N., Dolan C.V., Dunn E.C., Eley T.C., Escott-Price V., Kiadeh FFH, Finucane H.K., Forstner A.J., Frank J., Gaspar H.A., Gill M., Goes F.S., Gordon S.D., Grove J., Hall L.S., Hansen C.S., Hansen T.F., Herms S., Hickie I.B., Hoffmann P., Homuth G., Horn C., Hottenga J.J., Hougaard D.M., Ising M., Jansen R., Jorgenson E., Knowles J.A., Kohane I.S., Kraft J., Kretzschmar W.W., Krogh J., Kutalik Z., Li Y., Lind P.A., MacIntyre D.J., MacKinnon D.F., Maier R.M., Maier W., Marchini J., Mbarek H., McGrath P., McGuffin P., Medland S.E., Mehta D., Middeldorp C.M., Mihailov E., Milaneschi Y., Milani L., Mondimore F.M., Montgomery G.W., Mostafavi S., Mullins N., Nauck M., Ng B., Nivard M.G., Nyholt D.R., O'Reilly P.F., Oskarsson H., Owen M.J., Painter J.N., Pedersen C.B., Pedersen M.G., Peterson R.E., Pettersson E., Peyrot W.J., Pistis G., Posthuma D., Quiroz J.A., Qvist P., Rice J.P., Riley B.P., Rivera M., Mirza S.S., Schoevers R., Schulte E.C., Shen L., Shi J., Shyn S.I., Sigurdsson E., Sinnamon GCB, Smit J.H., Smith D.J., Stefansson H., Steinberg S., Streit F., Strohmaier J., Tansey K.E., Teismann H., Teumer A., Thompson W., Thomson P.A., Thorgeirsson T.E., Traylor M., Treutlein J., Trubetskoy V., Uitterlinden A.G., Umbricht D., Van der Auwera S., van Hemert A.M., Viktorin A., Visscher P.M., Wang Y., Webb B.T., Weinsheimer S.M., Wellmann J., Willemsen G., Witt S.H., Wu Y., Xi H.S., Yang J., Zhang F., Arolt V., Baune B.T., Berger K., Boomsma D.I., Cichon S., Dannlowski U., de Geus EJC, DePaulo J.R., Domenici E., Domschke K., Esko T., Grabe H.J., Hamilton S.P., Hayward C., Heath A.C., Kendler K.S., Kloiber S., Lewis G., Li Q.S., Lucae S., Madden PAF, Magnusson P.K., Martin N.G., McIntosh A.M., Metspalu A., Mors O., Mortensen P.B., Müller-Myhsok B., Nordentoft M., Nöthen M.M., O'Donovan M.C., Paciga S.A., Pedersen N.L., Penninx BWJH, Perlis R.H., Porteous D.J., Potash J.B., Preisig M., Rietschel M., Schaefer C., Schulze T.G., Smoller J.W., Stefansson K., Tiemeier H., Uher R., Völzke H., Weissman M.M., Werge T., Lewis C.M., Levinson D.F., Breen G., Børglum A.D., Sullivan P.F.

ISSN

2041-1723 (Electronic)

ISSN-L

2041-1723

Publication state

Published

Issued date

11/06/2019

Peer-reviewed

Oui

Volume

Number

Pages

2548

Language

english

Notes

Publication types: Journal Article
Publication Status: epublish

Abstract

Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.

URN

urn:nbn:ch:serval-BIB_E27A7F7B67AB7

OAI-PMH

oai:serval.unil.ch:BIB_E27A7F7B67AB

DOI

10.1038/s41467-019-10461-0

Pubmed

31186427

Web of science

000470968400008

Open Access

Yes