CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions.

Détails

ID Serval
serval:BIB_E261C93B68A9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions.
Périodique
EMBO Reports
Auteur(s)
Schneider K., Köcher T., Andersin T., Kurzchalia T., Schibler U., Gatfield D.
ISSN
1469-3178 (Electronic)
ISSN-L
1469-221X
Statut éditorial
Publié
Date de publication
2012
Volume
13
Numéro
12
Pages
1138-1144
Langue
anglais
Résumé
In mammals, transcriptional autorepression by Period (PER) and Cryptochrome (CRY) protein complexes is essential for the generation of circadian rhythms. We have identified CAVIN-3 as a new, cytoplasmic PER2-interacting protein influencing circadian clock properties. Thus, CAVIN-3 loss- and gain-of-function shortened and lengthened, respectively, the circadian period in fibroblasts and affected PER:CRY protein abundance and interaction. While depletion of protein kinase Cδ (PKCδ), a known partner of CAVIN-3, had little effect on circadian gene expression, CAVIN-3 required the PKCδ-binding site to exert its effect on period length. This suggests the involvement of yet uncharacterized protein kinases. Finally, CAVIN-3 activity in circadian gene expression was independent of caveolae.
Mots-clé
Cavin-3, Caveolin1, mammalian circadian gene expression, Period 2-interacting proteins, period length
Pubmed
Open Access
Oui
Création de la notice
12/12/2012 12:25
Dernière modification de la notice
20/08/2019 17:06
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