Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia: a prospective study in 24 spinal cord injury patients.
Details
Serval ID
serval:BIB_E25D9994F35D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia: a prospective study in 24 spinal cord injury patients.
Journal
Journal of Urology
ISSN
0022-5347 (Print)
ISSN-L
0022-5347
Publication state
Published
Issued date
1996
Volume
155
Number
3
Pages
1023-1029
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
PURPOSE: The paralytic effect of botulinum-A toxin injections on the external urethral sphincter was investigated prospectively in patients with neurogenic voiding disorders.
MATERIALS AND METHODS: Transurethral versus transperineal botulinum-A toxin injections were performed in 24 spinal cord injury male patients with detrusor-sphincter dyssynergia and the respective efficacy was compared.
RESULTS: In 21 of 24 patients detrusor-sphincter dyssynergia was significantly improved with a concomitant decrease in post-void residual volumes in most cases. Botulinum-A toxin effects lasted 3 to 9 months, making reinjections necessary.
CONCLUSIONS: Although costly, botulinum-A toxin injections, which aim at suppressing detrusor-sphincter dyssynergia but not bladder neck dyssynergia, appear to be a valid alternative for patients who do not desire surgery or are unable to perform self-catheterization.
MATERIALS AND METHODS: Transurethral versus transperineal botulinum-A toxin injections were performed in 24 spinal cord injury male patients with detrusor-sphincter dyssynergia and the respective efficacy was compared.
RESULTS: In 21 of 24 patients detrusor-sphincter dyssynergia was significantly improved with a concomitant decrease in post-void residual volumes in most cases. Botulinum-A toxin effects lasted 3 to 9 months, making reinjections necessary.
CONCLUSIONS: Although costly, botulinum-A toxin injections, which aim at suppressing detrusor-sphincter dyssynergia but not bladder neck dyssynergia, appear to be a valid alternative for patients who do not desire surgery or are unable to perform self-catheterization.
Keywords
Adolescent, Adult, Anti-Dyskinesia Agents/administration & dosage, Botulinum Toxins/administration & dosage, Cystoscopy, Humans, Injections/methods, Male, Middle Aged, Perineum, Prospective Studies, Spinal Cord Injuries/complications, Urethra, Urinary Bladder, Neurogenic/etiology, Urinary Bladder, Neurogenic/physiopathology, Urodynamics
Pubmed
Web of science
Create date
05/11/2014 13:13
Last modification date
20/08/2019 17:06
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