Notch signaling regulates follicular helper T cell differentiation.

Détails

ID Serval
serval:BIB_E252B83EEB58
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Notch signaling regulates follicular helper T cell differentiation.
Périodique
Journal of Immunology
Auteur(s)
Auderset F., Schuster S., Fasnacht N., Coutaz M., Charmoy M., Koch U., Favre S., Wilson A., Trottein F., Alexander J., Luther S.A., Macdonald H.R., Radtke F., Tacchini-Cottier F.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
2013
Volume
191
Numéro
5
Pages
2344-2350
Langue
anglais
Résumé
Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but their control is not fully understood. In this study, we show that Notch signaling in T cells is a major player in the development and function of TFH cells. T cell-specific gene ablation of Notch1 and Notch2 impaired differentiation of TFH cells in draining lymph nodes of mice immunized with T-dependent Ags or infected with parasites. Impaired TFH cell differentiation correlated with deficient germinal center development and the absence of high-affinity Abs. The impact of loss of Notch on TFH cell differentiation was largely independent of its effect on IL-4. These results show a previously unknown role for Notch in the regulation of TFH cell differentiation and function with implications for the control of this T cell population.
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/10/2013 9:09
Dernière modification de la notice
20/08/2019 17:06
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