Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala.

Details

Serval ID
serval:BIB_E230041A9254
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala.
Journal
Pharmacological Reports
Author(s)
Allaman I., Papp M., Kraftsik R., Fiumelli H., Magistretti P.J., Martin J.L.
ISSN
1734-1140
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
60
Number
6
Pages
1001-1007
Language
english
Notes
Texte intégral : http://www.if-pan.krakow.pl/pjp/pdf/2008/6_1001.pdf
Abstract
Accumulating evidence supports a role for brain-derived neurotrophic factor (BDNF) in depression. However, most of these studies have been performed in animal models that have a low face validity with regard to the human disease. Here, we examined the regulation of BDNF expression in the hippocampus and amygdala of rats subjected to the chronic mild stress (CMS) model of depression, a paradigm that induces anhedonia, a core symptom of depression. We found that exposure of rats to the CMS paradigm did not modulate BDNF mRNA expression in the hippocampus and amygdala. In addition, chronic administration of imipramine, which reversed CMS-induced anhedonia, did not alter BDNF mRNA expression in these limbic structures.
Keywords
Amygdala/metabolism, Animals, Brain-Derived Neurotrophic Factor/genetics, Chronic Disease, Depression/metabolism, Disease Models, Animal, Gene Expression Regulation, Hippocampus/metabolism, Male, RNA, Messenger/analysis, Rats, Rats, Wistar, Stress, Psychological/metabolism
Pubmed
Web of science
Create date
30/01/2009 11:13
Last modification date
20/08/2019 17:06
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