Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Interferon beta adenoviral gene therapy in a patient with ovarian cancer.
Nature Clinical Practice Oncology
Publication types: Case Reports ; Journal Article ; Research Support, N.I.H., ExtramuralPublication Status: ppublish
Background A 47-year-old woman with a history of ovarian cancer and a 6-year disease-free remission presented with dyspnea and increased abdominal girth. The patient was found to have ascites and a large left pleural effusion, both of which contained malignant cells consistent with recurrent ovarian cancer. Her disease progressed despite treatment with chemotherapeutic and hormonal agents. She was then enrolled in a phase I clinical trial of adenoviral-mediated interferon beta gene therapy. Investigations Abdominal and chest CT scans, 2-[(18)F]fluoro-2-deoxyglucose PET scan, viral cultures, interferon cytokine analysis, immunophenotyping, and tumor cytotoxicity analyses. Diagnosis Stage IV ovarian cancer with malignant ascites and pleural effusion. Management Tunneled pleural catheter and intrapleural adenoviral-mediated interferon beta gene therapy.
Adenoviridae, Ascites/etiology, Female, Genetic Therapy, Genetic Vectors, Humans, Interferon-beta/genetics, Interferon-beta/therapeutic use, Middle Aged, Ovarian Neoplasms/complications, Ovarian Neoplasms/therapy, Pleural Effusion/etiology, T-Lymphocytes/immunology, Treatment Outcome
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